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Efficacy and feasibility of presurgical exercise in bladder cancer patients scheduled for open radical cystectomy
Taaffe, Dennis R. McCombie, Steve P. Galvão, Daniel A. Newton, Robert U. La Bianca, Shane Chambers, Suzanne K. Spry, Nigel Singh, Favil Lopez, Pedro Schumacher, Oliver
Taaffe, Dennis R.
McCombie, Steve P.
Galvão, Daniel A.
Newton, Robert U.
La Bianca, Shane
Chambers, Suzanne K.
Spry, Nigel
Singh, Favil
Lopez, Pedro
Schumacher, Oliver
Abstract
Purpose
This study aimed to examine the feasibility and potential efficacy of presurgical exercise in patients with bladder cancer scheduled for open radical cystectomy with follow-up postsurgery.
Methods
Prospective single-group design with assessments at baseline, presurgery, and 3 months postsurgery was used in this study. Multimodal supervised resistance and aerobic exercise was undertaken 2–3 d·wk−1 at moderate intensity for a median of 3.5 wk (interquartile range [IQR] = 1.3–5.6). Feasibility was assessed by recruitment and completion rates, patient safety, program tolerance, adherence, and compliance. Lean and fat mass were assessed by dual-energy x-ray absorptiometry, physical function by a battery of tests (chest press and leg press strength, 6-min walk test [6MWT], timed up-and-go, repeated chair rise), and quality of life (QoL), psychological distress, and body image by questionnaire. Hospital length of stay (LOS) and complications were assessed by medical records.
Results
Thirty-seven patients were referred with 20 recruited (67.3 ± 12.2 yr) and a presurgery intervention completion rate of 80% (16 of 20). The individual median program adherence was 100.0% (IQR = 89.4–100.0) with compliance of 100.0% (IQR = 90.5–100.0) for resistance exercise and 81.8% (IQR = 55.0–99.5) for aerobic exercise. There were no exercise-related adverse events. Body composition did not change presurgery; however, there were improvements (P < 0.05) in leg press strength (16%), 6MWT distance (8%), timed up-and-go (12%), chair rise (10%), and multiple QoL domains including mental health. Median LOS was 8.0 d (IQR = 7.0, 15.0). Postsurgery, there were declines in components of QoL and apparent body image dissatisfaction.
Conclusions
A preradical cystectomy exercise program is feasible, safe, and well tolerated with improvements in physical function and QoL. Supervised multimodal exercise in bladder cancer patients before cystectomy can enhance physical and mental health potentially buffering the effects of surgery.
Keywords
bladder cancer, exercise, cystectomy, neoadjuvant chemotherapy
Date
2023
Type
Journal article
Journal
Medicine and Science in Sports and Exercise
Book
Volume
55
Issue
7
Page Range
1123-1132
Article Number
ACU Department
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
License
All rights reserved
File Access
Controlled