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Cortical thickness and resting-state cardiac function across the lifespan : A cross-sectional pooled mega-analysis
Koenig, Julian Abler, Birgit Agartz, Ingrid Åkerstedt, Torbjörn Andreassen, Ole A. Anthony, Mia Bär, Karl-Jürgen Bertsch, Katja Brown, Rebecca C. Brunner, Romuald
Koenig, Julian
Abler, Birgit
Agartz, Ingrid
Åkerstedt, Torbjörn
Andreassen, Ole A.
Anthony, Mia
Bär, Karl-Jürgen
Bertsch, Katja
Brown, Rebecca C.
Brunner, Romuald
Author
Koenig, Julian
Abler, Birgit
Agartz, Ingrid
Åkerstedt, Torbjörn
Andreassen, Ole A.
Anthony, Mia
Bär, Karl-Jürgen
Bertsch, Katja
Brown, Rebecca C.
Brunner, Romuald
Carnevali, Luca
Critchley, Hugo D.
Cullen, Kathryn R.
de Geus, Eco J. C.
de la Cruz, Feliberto
Dziobek, Isabel
Ferger, Marc D.
Fischer, Håkan
Flor, Herta
Gaebler, Michael
Gianaros, Peter J.
Giummarra, Melita J.
Greening, Steven G.
Guendelman, Simon
Heathers, James A. J.
Herpertz, Sabine C.
Hu, Mandy X.
Jentschke, Sebastian
Kaess, Michael
Kaufmann, Tobias
Klimes-Dougan, Bonnie
Koelsch, Stefan
Krauch, Marlene
Kumral, Deniz
Lamers, Femke
Lee, Tae-Ho
Lekander, Mats
Lin, Feng
Lotze, Martin
Makovac, Elena
Mancini, Matteo
Mancke, Falk
Månsson, Kristoffer N. T.
Manuck, Stephen B.
Mather, Mara
Meeten, Frances
Min, Jungwon
Mueller, Bryon
Muench, Vera
Nees, Frauke
Nga, Lin
Nilsonne, Gustav
Ordonez Acuna, Daniela
Osnes, Berge
Ottaviani, Cristina
Penninx, Brenda W. J. H.
Ponzio, Allison
Poudel, Govinda R.
Reinelt, Janis
Ren, Ping
Sakaki, Michiko
Schumann, Andy
Sørensen, Lin
Specht, Karsten
Straub, Joana
Tamm, Sandra
Thai, Michelle
Thayer, Julian F.
Ubani, Benjamin
van der Mee, Denise J.
van Velzen, Laura S.
Ventura-Bort, Carlos
Villringer, Arno
Watson, David R.
Wei, Luqing
Wendt, Julia
Schreiner, Melinda Westlund
Westlye, Lars T.
Weymar, Mathias
Winkelmann, Tobias
Wu, Guo-Rong
Yoo, Hyun Joo
Quintana, Daniel S.
Abler, Birgit
Agartz, Ingrid
Åkerstedt, Torbjörn
Andreassen, Ole A.
Anthony, Mia
Bär, Karl-Jürgen
Bertsch, Katja
Brown, Rebecca C.
Brunner, Romuald
Carnevali, Luca
Critchley, Hugo D.
Cullen, Kathryn R.
de Geus, Eco J. C.
de la Cruz, Feliberto
Dziobek, Isabel
Ferger, Marc D.
Fischer, Håkan
Flor, Herta
Gaebler, Michael
Gianaros, Peter J.
Giummarra, Melita J.
Greening, Steven G.
Guendelman, Simon
Heathers, James A. J.
Herpertz, Sabine C.
Hu, Mandy X.
Jentschke, Sebastian
Kaess, Michael
Kaufmann, Tobias
Klimes-Dougan, Bonnie
Koelsch, Stefan
Krauch, Marlene
Kumral, Deniz
Lamers, Femke
Lee, Tae-Ho
Lekander, Mats
Lin, Feng
Lotze, Martin
Makovac, Elena
Mancini, Matteo
Mancke, Falk
Månsson, Kristoffer N. T.
Manuck, Stephen B.
Mather, Mara
Meeten, Frances
Min, Jungwon
Mueller, Bryon
Muench, Vera
Nees, Frauke
Nga, Lin
Nilsonne, Gustav
Ordonez Acuna, Daniela
Osnes, Berge
Ottaviani, Cristina
Penninx, Brenda W. J. H.
Ponzio, Allison
Poudel, Govinda R.
Reinelt, Janis
Ren, Ping
Sakaki, Michiko
Schumann, Andy
Sørensen, Lin
Specht, Karsten
Straub, Joana
Tamm, Sandra
Thai, Michelle
Thayer, Julian F.
Ubani, Benjamin
van der Mee, Denise J.
van Velzen, Laura S.
Ventura-Bort, Carlos
Villringer, Arno
Watson, David R.
Wei, Luqing
Wendt, Julia
Schreiner, Melinda Westlund
Westlye, Lars T.
Weymar, Mathias
Winkelmann, Tobias
Wu, Guo-Rong
Yoo, Hyun Joo
Quintana, Daniel S.
Abstract
Understanding the association between autonomic nervous system [ANS] function and brain morphology across the lifespan provides important insights into neurovisceral mechanisms underlying health and disease. Resting-state ANS activity, indexed by measures of heart rate [HR] and its variability [HRV] has been associated with brain morphology, particularly cortical thickness [CT]. While findings have been mixed regarding the anatomical distribution and direction of the associations, these inconsistencies may be due to sex and age differences in HR/HRV and CT. Previous studies have been limited by small sample sizes, which impede the assessment of sex differences and aging effects on the association between ANS function and CT. To overcome these limitations, 20 groups worldwide contributed data collected under similar protocols of CT assessment and HR/HRV recording to be pooled in a mega-analysis (N = 1,218 (50.5% female), mean age 36.7 years (range: 12–87)). Findings suggest a decline in HRV as well as CT with increasing age. CT, particularly in the orbitofrontal cortex, explained additional variance in HRV, beyond the effects of aging. This pattern of results may suggest that the decline in HRV with increasing age is related to a decline in orbitofrontal CT. These effects were independent of sex and specific to HRV; with no significant association between CT and HR. Greater CT across the adult lifespan may be vital for the maintenance of healthy cardiac regulation via the ANS—or greater cardiac vagal activity as indirectly reflected in HRV may slow brain atrophy. Findings reveal an important association between CT and cardiac parasympathetic activity with implications for healthy aging and longevity that should be studied further in longitudinal research.
Keywords
aging, autonomic nervous system, cortical thickness, heart rate, heart rate variability, sex
Date
2021
Type
Journal article
Journal
Psychophysiology
Book
Volume
58
Issue
7
Page Range
1-16
Article Number
Article e13688
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
Published as ‘gold’ (paid) open access
License
CC BY-NC 4.0
File Access
Open