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Editorial: Cross Adaptation and Cross Tolerance in Human Health and Disease
Ben James Lee Oliver R Gibson Charles Douglas Thake Mike Tipton John Hawley James D Cotter
Ben James Lee
Oliver R Gibson
Charles Douglas Thake
Mike Tipton
John Hawley
James D Cotter
Abstract
[Extract] Human physiological responses to heat, cold, hypoxia, microgravity, hyperbaria, hypobaria, and fasting are well-studied in isolation. However, in the natural world these stressors are often combined or experienced sequentially (Tipton, 2012). Studies examining human responses to these more realistic, yet relatively complex, circumstances remain sparse, but could provide important insights into an emerging area within human physiology: cross-adaptation (Figure 1) (Lunt et al., 2010; Gibson et al., 2017). Much of the current state of knowledge involves data demonstrating benefits of exercising in hot conditions, prior to performance in hypoxia (Heled et al., 2012; Lee et al., 2014a,b, 2016; Gibson et al., 2015; White et al., 2016; Salgado et al., 2017), with cold to hypoxia (Lunt et al., 2010), hypoxia to heat (Sotiridis et al., 2018), combined stressors (Takeno et al., 2001; Neal et al., 2017), and more mechanistic (signaling) data from animal models exposed to substantive volumes of stress (Maloyan and Horowitz, 2002, 2005). The role of nutrient availability and the nutrient-exercise interactions which drive phenotypic adaptations to skeletal muscle exposed to a multitude of stressors is also a growing field of interest (Hawley et al., 2018). This research topic includes publications which address both clinical and exercise-centric aspects allied to Cross-adaptation and Cross-tolerance in Human Health and Disease.
Keywords
heat, adaptation, preconditining, hypoxia, nutrition, dehydration
Date
2019
Type
Journal article
Journal
Frontiers in Physiology
Book
Volume
9
Issue
Page Range
1-3
Article Number
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
Published as ‘gold’ (paid) open access
License
CC BY 4.0
File Access
Open