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Influence of fetal glutathione S-transferase copy number variants on adverse reproductive outcomes
Bustamante, Mariona Danileviciute, Asta Espinosa, Ana González, Juan R. Subirana, I. Cordier, Sylvaine Chevrier, Cécile Chatzi, Leda Grazuleviciene, Regina Sunyer, Jordi
Bustamante, Mariona
Danileviciute, Asta
Espinosa, Ana
González, Juan R.
Subirana, I.
Cordier, Sylvaine
Chevrier, Cécile
Chatzi, Leda
Grazuleviciene, Regina
Sunyer, Jordi
Abstract
A nested case–control association study was designed to investigate the influence of maternal and fetal copy number variants (CNVs) on reproductive outcomes. Genotypes of ten CNVs encompassing GST and CYP genes were assessed. Significant associations were only found for child CNV genotypes. In particular, the child GSTM1 insertion allele was associated with prematurity protection (odds ratio, 95% CI: 0.67, 0.51–0.89; P < 0.01), whereas the child GSTT2B insertion allele was associated with an increased risk of being small for gestational age (odds ratio, 95% CI: 1.33, 1.07–1.67; P = 0.01). The study highlights the role of the fetal genome in prenatal development and also the need to analyse CNVs in a systematic manner.
Keywords
copy number variant, glutathione s-transferase, preterm, small for gestational age
Date
2012
Type
Journal article
Journal
BJOG: An International Journal of Obstetrics and Gynaecology
Book
Volume
119
Issue
9
Page Range
1141-1146
Article Number
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
License
File Access
Controlled