Loading...
High-resolution in vivo imaging of bone and joints: a window to microarchitecture
Geusens, P. Geusens, P. Chapurlat, Roland D. Chapurlat, Roland D. Schett, G. Ghasem-Zadeh, Ali Ghasem-Zadeh, Ali Seeman, Ego De Jong, J. Van Den Bergh, J.
Geusens, P.
Geusens, P.
Chapurlat, Roland D.
Chapurlat, Roland D.
Schett, G.
Ghasem-Zadeh, Ali
Ghasem-Zadeh, Ali
Seeman, Ego
De Jong, J.
Van Den Bergh, J.
Abstract
Imaging is essential to the evaluation of bone and joint diseases, and the digital era has contributed to an exponential increase in the number of publications on noninvasive analytical techniques for the quantification of changes to bone and joints that occur in health and in disease. One such technique is high-resolution peripheral quantitative CT (HR-pQCT), which has introduced a new dimension in the imaging of bone and joints by providing images that are both 3D and at high resolution (82 μm isotropic voxel size), with a low level of radiation exposure (3–5 μSv). HR-pQCT enables the analysis of cortical and trabecular properties separately and to apply micro-finite element analysis for calculating bone biomechanical competence in vivo at the distal sites of the skeleton (distal radius and distal tibia). Moreover, HR-pQCT makes possible the in vivo assessment of the spatial distribution, dimensions and delineation of cortical bone erosions, osteophytes, periarticular cortical and trabecular microarchitecture, and 3D joint-space volume of the finger joints and wrists. HR-pQCT is, therefore, a technique with a high potential for improving our understanding of bone and joint diseases at the microarchitectural level.
Keywords
Date
2014
Type
Journal article
Journal
Nature Reviews Rheumatology
Book
Volume
10
Issue
5
Page Range
304-313
Article Number
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
License
File Access
Controlled