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Early-life environmental exposures and blood pressure in children

Warembourg, Charline
; 
Maitre, Léa
; 
Tamayo-Uria, Ibon
; 
Fossati, Serena
; 
Roumeliotaki, Theano
; 
Aasvang, Gunn Marit
; 
Andrusaityte, Sandra
; 
Casas, Maribel
; 
Cequier, Enrique
; 
Chatzi, Leda
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Author
Warembourg, Charline
Maitre, Léa
Tamayo-Uria, Ibon
Fossati, Serena
Roumeliotaki, Theano
Aasvang, Gunn Marit
Andrusaityte, Sandra
Casas, Maribel
Cequier, Enrique
Chatzi, Leda
Dedele, Audrius
González, Juan-Ramon
Gražulevičienė, Regina
Haug, Line Smastuen
Hernandez-Ferrer, Carles
Heude, Barbara
Karachaliou, Marianna
Krog, Norun Hjertager
McEachan, Rosemary R. C.
Nieuwenhuijsen, Mark
Petraviciene, Inga
Quentin, Joane
Robinson, Oliver
Sakhi, Amrit Kaur
Slama, Rémy
Thomsen, Cathrine
Urquiza, Jose
Vafeiadi, Marina
West, Jane
Wright, John
Vrijheid, Martine
Basagaña, Xavier
Abstract
Background Growing evidence exists about the fetal and environmental origins of hypertension, but mainly limited to single-exposure studies. The exposome has been proposed as a more holistic approach by studying many exposures simultaneously. Objectives This study aims to evaluate the association between a wide range of prenatal and postnatal exposures and blood pressure (BP) in children. Methods Systolic and diastolic BP were measured among 1,277 children from the European HELIX (Human Early-Life Exposome) cohort aged 6 to 11 years. Prenatal (n = 89) and postnatal (n = 128) exposures include air pollution, built environment, meteorology, natural spaces, traffic, noise, chemicals, and lifestyles. Two methods adjusted for confounders were applied: an exposome-wide association study considering the exposures independently, and the deletion-substitution-addition algorithm considering all the exposures simultaneously. Results Decreases in systolic BP were observed with facility density (β change for an interquartile-range increase in exposure: −1.7 mm Hg [95% confidence interval (CI): −2.5 to −0.8 mm Hg]), maternal concentrations of polychlorinated biphenyl 118 (−1.4 mm Hg [95% CI: −2.6 to −0.2 mm Hg]) and child concentrations of dichlorodiphenyldichloroethylene (DDE: −1.6 mm Hg [95% CI: −2.4 to −0.7 mm Hg]), hexachlorobenzene (−1.5 mm Hg [95% CI: −2.4 to −0.6 mm Hg]), and mono−benzyl phthalate (−0.7 mm Hg [95% CI: −1.3 to −0.1 mm Hg]), whereas increases in systolic BP were observed with outdoor temperature during pregnancy (1.6 mm Hg [95% CI: 0.2 to 2.9 mm Hg]), high fish intake during pregnancy (2.0 mm Hg [95% CI: 0.4 to 3.5 mm Hg]), maternal cotinine concentrations (1.2 mm Hg [95% CI: -0.3 to 2.8 mm Hg]), and child perfluorooctanoate concentrations (0.9 mm Hg [95% CI: 0.1 to 1.6 mm Hg]). Decreases in diastolic BP were observed with outdoor temperature at examination (−1.4 mm Hg [95% CI: −2.3 to −0.5 mm Hg]) and child DDE concentrations (−1.1 mm Hg [95% CI: −1.9 to −0.3 mm Hg]), whereas increases in diastolic BP were observed with maternal bisphenol-A concentrations (0.7 mm Hg [95% CI: 0.1 to 1.4 mm Hg]), high fish intake during pregnancy (1.2 mm Hg [95% CI: −0.2 to 2.7 mm Hg]), and child copper concentrations (0.9 mm Hg [95% CI: 0.3 to 1.6 mm Hg]). Conclusions This study suggests that early-life exposure to several chemicals, as well as built environment and meteorological factors, may affect BP in children.
Keywords
blood pressure, chemicals, children, cohort, environment, epidemiology, exposome
Date
2019
Type
Journal article
Journal
Journal of the American College of Cardiology
Book
Volume
74
Issue
10
Page Range
1317-1328
Article Number
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Collections
Mary MacKillop Institute for Health Research
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URI
https://hdl.handle.net/20.500.14802/24427
Relation URI
DOI
10.1016/j.jacc.2019.06.069
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