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Maximizing cellular adaptation to endurance exercise in skeletal muscle
Hawley, John Lundby, Carsten Cotter, James D. Burke, Louise
Hawley, John
Lundby, Carsten
Cotter, James D.
Burke, Louise
Abstract
The application of molecular techniques to exercise biology has provided novel insight into the complexity and breadth of intracellular signaling networks involved in response to endurance-based exercise. Here we discuss several strategies that have high uptake by athletes and, on mechanistic grounds, have the potential to promote cellular adaptation to endurance training in skeletal muscle. Such approaches are based on the underlying premise that imposing a greater metabolic load and provoking extreme perturbations in cellular homeostasis will augment acute exercise responses that, when repeated over months and years, will amplify training adaptation.
Keywords
altitude, AMPK, athlete, carbohydrate availability, glycogen, heat acclimation, hypoxia, PGC1α
Date
2018
Type
Journal article
Journal
Cell Metabolism
Book
Volume
27
Issue
5
Page Range
962-976
Article Number
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Centre for Exercise and Nutrition
Faculty of Health Sciences
Centre for Exercise and Nutrition
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Relation URI
Source URL
Event URL
Open Access Status
License
File Access
Controlled