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Associations of neighborhood environment with brain imaging outcomes in the Australian imaging, biomarkers and lifestyle cohort
Cerin, Ester Rainey-Smith, Stephanie R. Ames, David Lautenschlager, Nicola T. Macaulay, Stuart Lance Fowler, Chris J. Robertson, Jane M. Rowe, Christopher C. Maruff, Paul Thomas Martins, Ralph N.
Cerin, Ester
Rainey-Smith, Stephanie R.
Ames, David
Lautenschlager, Nicola T.
Macaulay, Stuart Lance
Fowler, Chris J.
Robertson, Jane M.
Rowe, Christopher C.
Maruff, Paul Thomas
Martins, Ralph N.
Abstract
Introduction: “Walkable” neighborhoods offer older adults opportunities for activities that may benefit cognition-related biological mechanisms. These have not previously been examined in this context. Methods: We objectively assessed neighborhood walkability for participants (n 5 146) from the Australian Imaging, Biomarkers and Lifestyle study with apolipoprotein E (APOE) genotype and two 18-month-apart brain volumetric and/or amyloid b burden assessments. Linear mixed models estimated associations of neighborhood walkability with levels and changes in brain imaging outcomes, the moderating effect of APOE ε4 status, and the extent to which associations were explained by physical activity. Results: Cross-sectionally, neighborhood walkability was predictive of better neuroimaging outcomes except for left hippocampal volume. These associations were to a small extent explained by physical activity. APOE ε4 carriers showed slower worsening of outcomes if living in walkable neighborhoods. Discussion: These findings indicate associations between neighborhood walkability and brain imaging measures (especially in APOE ε4 carriers) minimally attributable to physical activity.
Keywords
Date
2017
Type
Journal article
Journal
Alzheimer's and Dementia
Book
Volume
13
Issue
4
Page Range
388-398
Article Number
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
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Open Access Status
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File Access
Controlled