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Bone-adiposity cross-talk: implications for pediatric obesity
Chaplais, Elodie Thivel, David Greene, David Dutheil, Frederic Duche, Pascale Naughton, Geraldine Courteix, Daniel
Chaplais, Elodie
Thivel, David
Greene, David
Dutheil, Frederic
Duche, Pascale
Naughton, Geraldine
Courteix, Daniel
Abstract
The rising prevalence of overweight and obesity among pediatric populations has become a major global concern. The objective of this review is to demonstrate potential interactions between the products released by fat tissue and the hormonal production of bone tissue in obese children and adolescents. Advancing the understanding of the complex interactions between adipocyte and osteocyte activities may contribute to the mechanistic understanding of the body’s responses to weight loss during adolescence. This knowledge could also reveal any side effects encountered with these interventions. Currently, the concept of bone-adiposity crosstalk has not been fully elucidated, and the mechanisms remain controversial. Understanding the local interactions between the released products by fat tissue and hormones produced in bone tissue requires further investigations.
Keywords
Date
2015
Type
Journal article
Journal
Journal of Bone and Mineral Metabolism
Book
Volume
33
Issue
6
Page Range
592-602
Article Number
ACU Department
School of Behavioural and Health Sciences
Faculty of Health Sciences
Faculty of Health Sciences
Relation URI
Source URL
Event URL
Open Access Status
License
File Access
Controlled