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Iron accumulation in the basal ganglia in Huntington's disease: Cross-sectional data from the IMAGE-HD study
Dominguez, Juan F. Ng, Amanda C. L. Poudel, Govinda Stout, Julie C. Churchyard, A. Chua, Phyllis Egan, Gary F. Georgiou-Karistianis, Nellie
Dominguez, Juan F.
Ng, Amanda C. L.
Poudel, Govinda
Stout, Julie C.
Churchyard, A.
Chua, Phyllis
Egan, Gary F.
Georgiou-Karistianis, Nellie
Abstract
Objectives
To measure iron accumulation in the basal ganglia in Huntington's disease (HD) using quantitative susceptibility mapping (QSM), and to ascertain its relevance in terms of clinical and disease severity.
Methods
In this cross-sectional investigation, Embedded Image weighted imaging was undertaken on 31 premanifest HD, 32 symptomatic HD and 30 control participants as part of the observational IMAGE-HD study. Group differences in iron accumulation were ascertained with QSM. Associations between susceptibility values and disease severity were also investigated.
Results
Compared with controls, both premanifest and symptomatic HD groups showed significantly greater iron content in pallidum, putamen and caudate. Additionally, iron accumulation in both putamen and caudate was significantly associated with disease severity.
Conclusions
These findings provide the first evidence that QSM is sensitive to iron deposition in subcortical target areas across premanifest and symptomatic stages of HD. Such findings could open up new avenues for biomarker development and therapeutic intervention.
Keywords
Date
2016
Type
Journal article
Journal
Journal of Neurology, Neurosurgery and Psychiatry
Book
Volume
87
Issue
5
Page Range
545-549
Article Number
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
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Relation URI
Source URL
Event URL
Open Access Status
License
File Access
Controlled