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The early-life exposome modulates the effect of polymorphic inversions on DNA methylation
Carreras-Gallo, Natàlia Cáceres, Alejandro Balagué-Dobón, Laura Ruiz-Arenas, Carlos Andrusaityte, Sandra Carracedo, Ángel Casas, Maribel Chatzi, Leda Grazuleviciene, Regina Gutzkow, Kristine Bjerve
Carreras-Gallo, Natàlia
Cáceres, Alejandro
Balagué-Dobón, Laura
Ruiz-Arenas, Carlos
Andrusaityte, Sandra
Carracedo, Ángel
Casas, Maribel
Chatzi, Leda
Grazuleviciene, Regina
Gutzkow, Kristine Bjerve
Author
Carreras-Gallo, Natàlia
Cáceres, Alejandro
Balagué-Dobón, Laura
Ruiz-Arenas, Carlos
Andrusaityte, Sandra
Carracedo, Ángel
Casas, Maribel
Chatzi, Leda
Grazuleviciene, Regina
Gutzkow, Kristine Bjerve
Lepeule, Johanna
Maitre, Léa
Nieuwenhuijsen, Mark
Slama, Remy
Stratakis, Nikos
Thomsen, Cathrine
Urquiza, Jose
Wright, John
Yang, Tiffany
Escaramís, Geòrgia
Bustamante, Mariona
Vrijheid, Martine
Pérez-Jurado, Luis A.
Gonzalez, Juan R.
Cáceres, Alejandro
Balagué-Dobón, Laura
Ruiz-Arenas, Carlos
Andrusaityte, Sandra
Carracedo, Ángel
Casas, Maribel
Chatzi, Leda
Grazuleviciene, Regina
Gutzkow, Kristine Bjerve
Lepeule, Johanna
Maitre, Léa
Nieuwenhuijsen, Mark
Slama, Remy
Stratakis, Nikos
Thomsen, Cathrine
Urquiza, Jose
Wright, John
Yang, Tiffany
Escaramís, Geòrgia
Bustamante, Mariona
Vrijheid, Martine
Pérez-Jurado, Luis A.
Gonzalez, Juan R.
Abstract
Polymorphic genomic inversions are chromosomal variants with intrinsic variability that play important roles in evolution, environmental adaptation, and complex traits. We investigated the DNA methylation patterns of three common human inversions, at 8p23.1, 16p11.2, and 17q21.31 in 1,009 blood samples from children from the Human Early Life Exposome (HELIX) project and in 39 prenatal heart tissue samples. We found inversion-state specific methylation patterns within and nearby flanking each inversion region in both datasets. Additionally, numerous inversion-exposure interactions on methylation levels were identified from early-life exposome data comprising 64 exposures. For instance, children homozygous at inv-8p23.1 and higher meat intake were more susceptible to TDH hypermethylation (P = 3.8 × 10−22); being the inversion, exposure, and gene known risk factors for adult obesity. Inv-8p23.1 associated hypermethylation of GATA4 was also detected across numerous exposures. Our data suggests that the pleiotropic influence of inversions during development and lifetime could be substantially mediated by allele-specific methylation patterns which can be modulated by the exposome.
Keywords
Date
2022
Type
Journal article
Journal
Communications Biology
Book
Volume
5
Issue
1
Page Range
1-13
Article Number
Article 455
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
Published as ‘gold’ (paid) open access
License
CC BY 4.0
File Access
Open