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The shape of things to come. Mapping spatiotemporal progression of striatal morphology in Huntington disease : The IMAGE-HD study
Wilkes, Fiona A. Jakabek, David Walterfang, Mark Velakoulis, Dennis Poudel, Govinda R. Stout, Julie C. Chua, Phyllis Egan, Gary F. Looi, Jeffrey C. L. Georgiou-Karistianis, Nellie
Wilkes, Fiona A.
Jakabek, David
Walterfang, Mark
Velakoulis, Dennis
Poudel, Govinda R.
Stout, Julie C.
Chua, Phyllis
Egan, Gary F.
Looi, Jeffrey C. L.
Georgiou-Karistianis, Nellie
Abstract
Mapping the spatiotemporal progression of neuroanatomical change in Huntington's Disease (HD) is fundamental to the development of bio-measures for prognostication. Statistical shape analysis to measure the striatum has been performed in HD, however there have been a limited number of longitudinal studies. To address these limitations, we utilised the Spherical Harmonic Point Distribution Method (SPHARM-PDM) to generate point distribution models of the striatum in individuals, and used linear mixed models to test for localised shape change over time in pre-manifest HD (pre-HD), symp-HD (symp-HD) and control individuals. Longitudinal MRI scans from the IMAGE-HD study were used (baseline, 18 and 30 months). We found significant differences in the shape of the striatum between groups. Significant group-by-time interaction was observed for the putamen bilaterally, but not for caudate. A differential rate of shape change between groups over time was observed, with more significant deflation in the symp-HD group in comparison with the pre-HD and control groups. CAG repeats were correlated with bilateral striatal shape in pre-HD and symp-HD. Robust statistical analysis of the correlates of striatal shape change in HD has confirmed the suitability of striatal morphology as a potential biomarker correlated with CAG-repeat length, and potentially, an endophenotype.
Keywords
striatum, endophenotype, biomarker, Huntington’s disease
Date
2023
Type
Journal article
Journal
Psychiatry Research: Neuroimaging
Book
Volume
335
Issue
Page Range
1-7
Article Number
Article 111717
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
Published as ‘gold’ (paid) open access
License
CC BY-NC-ND 4.0
File Access
Open
Notes
© 2023 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).