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Natural-cause mortality and long-term exposure to particle components: An analysis of 19 European cohorts within the multi-center ESCAPE project
Beelen, Rob Hoek, Gerard Raaschou-Nielsen, Ole Stafoggia, Massimo Andersen, Zorana Jovanovic Weinmayr, Gudrum Hoffman, Barbara Wolf, Kathrin Samoli, Evangelia Fischer, Paul H.
Beelen, Rob
Hoek, Gerard
Raaschou-Nielsen, Ole
Stafoggia, Massimo
Andersen, Zorana Jovanovic
Weinmayr, Gudrum
Hoffman, Barbara
Wolf, Kathrin
Samoli, Evangelia
Fischer, Paul H.
Author
Beelen, Rob
Hoek, Gerard
Raaschou-Nielsen, Ole
Stafoggia, Massimo
Andersen, Zorana Jovanovic
Weinmayr, Gudrum
Hoffman, Barbara
Wolf, Kathrin
Samoli, Evangelia
Fischer, Paul H.
Nieuwenhuijsen, Mark
Xun, Wei W.
Katsouyanni, Klea
Dimakopoulou, Konstantina
Marcon, Alessandro
Vartiainen, E.
Lanki, Timo
Yli-Tuomi, Tarja
Oftedal, Bente
Schwarze, Per E.
Nafstad, Per
De Faire, Ulf
Pedersen, Nancy L.
Ostenson, Claes-Goran
Fratiglioni, Laura
Penell, Johanna
Korek, Michal
Pershagen, Goran
Eriksen, Kirsten Thorup
Overvad, Kim
Sorensen, Mette
Eeftens, Marloes
Peeters, Petra H.
Meliefste, Kees
Wang, Meng
Bueno-de-Mesquita, H. Bas
Sugiri, Dorothea
Kramer, Ursula
Heinrich, Joachim
de Hoogh, Kees
Key, Timothy
Peters, Annette
Hampel, Regina
Concin, Hans
Nagel, Gabriel
Jaensch, Andrea
Ineichen, Alex
Tsai, Ming-Yi
Schaffner, Emmanuel
Probst-Hensch, Nicole M.
Schindler, Christian
Ragettli, Martina
Vilier, Alice
Clavel-Chapelon, Francoise
Declercq, Christophe
Ricceri, Fulvio
Sacerdote, Carlotta
Hoek, Gerard
Raaschou-Nielsen, Ole
Stafoggia, Massimo
Andersen, Zorana Jovanovic
Weinmayr, Gudrum
Hoffman, Barbara
Wolf, Kathrin
Samoli, Evangelia
Fischer, Paul H.
Nieuwenhuijsen, Mark
Xun, Wei W.
Katsouyanni, Klea
Dimakopoulou, Konstantina
Marcon, Alessandro
Vartiainen, E.
Lanki, Timo
Yli-Tuomi, Tarja
Oftedal, Bente
Schwarze, Per E.
Nafstad, Per
De Faire, Ulf
Pedersen, Nancy L.
Ostenson, Claes-Goran
Fratiglioni, Laura
Penell, Johanna
Korek, Michal
Pershagen, Goran
Eriksen, Kirsten Thorup
Overvad, Kim
Sorensen, Mette
Eeftens, Marloes
Peeters, Petra H.
Meliefste, Kees
Wang, Meng
Bueno-de-Mesquita, H. Bas
Sugiri, Dorothea
Kramer, Ursula
Heinrich, Joachim
de Hoogh, Kees
Key, Timothy
Peters, Annette
Hampel, Regina
Concin, Hans
Nagel, Gabriel
Jaensch, Andrea
Ineichen, Alex
Tsai, Ming-Yi
Schaffner, Emmanuel
Probst-Hensch, Nicole M.
Schindler, Christian
Ragettli, Martina
Vilier, Alice
Clavel-Chapelon, Francoise
Declercq, Christophe
Ricceri, Fulvio
Sacerdote, Carlotta
Abstract
Background
Studies have shown associations between mortality and long-term exposure to particulate matter air pollution. Few cohort studies have estimated the effects of the elemental composition of particulate matter on mortality.
Objectives
Our aim was to study the association between natural-cause mortality and long-term exposure to elemental components of particulate matter.
Methods
Mortality and confounder data from 19 European cohort studies were used. Residential exposure to eight a priori–selected components of particulate matter (PM) was characterized following a strictly standardized protocol. Annual average concentrations of copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc within PM size fractions ≤ 2.5 μm (PM2.5) and ≤ 10 μm (PM10) were estimated using land-use regression models. Cohort-specific statistical analyses of the associations between mortality and air pollution were conducted using Cox proportional hazards models using a common protocol followed by meta-analysis.
Results
The total study population consisted of 291,816 participants, of whom 25,466 died from a natural cause during follow-up (average time of follow-up, 14.3 years). Hazard ratios were positive for almost all elements and statistically significant for PM2.5 sulfur (1.14; 95% CI: 1.06, 1.23 per 200 ng/m3). In a two-pollutant model, the association with PM2.5 sulfur was robust to adjustment for PM2.5 mass, whereas the association with PM2.5 mass was reduced.
Conclusions
Long-term exposure to PM2.5 sulfur was associated with natural-cause mortality. This association was robust to adjustment for other pollutants and PM2.5.
Keywords
Date
2015
Type
Journal article
Journal
Environmental Health Perspectives
Book
Volume
123
Issue
6
Page Range
525-533
Article Number
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
Open access
License
File Access
Open