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Can genetic markers predict the sporadic form of Alzheimer’s disease? An updated review on genetic peripheral markers
Theron, Danelda Hopkins, Lloyd N. Sutherland, Heidi G. Griffiths, Lyn Fernandez, Francesca Elizabeth
Theron, Danelda
Hopkins, Lloyd N.
Sutherland, Heidi G.
Griffiths, Lyn
Fernandez, Francesca Elizabeth
Abstract
Alzheimer’s disease (AD) is the most common form of dementia that affects millions of individuals worldwide. Although the research over the last decades has provided new insight into AD pathophysiology, there is currently no cure for the disease. AD is often only diagnosed once the symptoms have become prominent, particularly in the late-onset (sporadic) form of AD. Consequently, it is essential to further new avenues for early diagnosis. With recent advances in genomic analysis and a lower cost of use, the exploration of genetic markers alongside RNA molecules can offer a key avenue for early diagnosis. We have here provided a brief overview of potential genetic markers differentially expressed in peripheral tissues in AD cases compared to controls, as well as considering the changes to the dynamics of RNA molecules. By integrating both genotype and RNA changes reported in AD, biomarker profiling can be key for developing reliable AD diagnostic tools.
Keywords
Alzheimer’s disease, genes, micro-RNA, circular-RNA, long-coding RNA, biomarkers, peripheral tissues
Date
2023
Type
Journal article
Journal
International Journal of Molecular Sciences
Book
Volume
24
Issue
17
Page Range
1-18
Article Number
Article 24
ACU Department
School of Behavioural and Health Sciences
Faculty of Health Sciences
Faculty of Health Sciences
Relation URI
Source URL
Event URL
Open Access Status
Published as ‘gold’ (paid) open access
License
CC BY 4.0
File Access
Open