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The Efficacy of Exercise Training for Cutaneous Microvascular Reactivity in the Foot in People with Diabetes and Obesity : Secondary Analyses from a Randomized Controlled Trial
Lanting, Sean Michael Way, Kimberley L. Sabag, A. Sultana, Rachelle Gerofi, James Johnson, Nathan Baker, Michael Kevin Keating, S Caterson, Ian Twigg, Stephen M.
Lanting, Sean Michael
Way, Kimberley L.
Sabag, A.
Sultana, Rachelle
Gerofi, James
Johnson, Nathan
Baker, Michael Kevin
Keating, S
Caterson, Ian
Twigg, Stephen M.
Abstract
It is unclear if cutaneous microvascular dysfunction associated with diabetes and obesity can be ameliorated with exercise. We investigated the effect of 12-weeks of exercise training on cutaneous microvascular reactivity in the foot. Thirty-three inactive adults with type 2 diabetes and obesity (55% male, 56.1 ± 7.9 years, BMI: 35.8 ± 5, diabetes duration: 7.9 ± 6.3 years) were randomly allocated to 12-weeks of either (i) moderate-intensity continuous training [50–60% peak oxygen consumption (VO2peak), 30–45 min, 3 d/week], (ii) low-volume high-intensity interval training (90% VO2peak, 1–4 min, 3 d/week) or (iii) sham exercise placebo. Post-occlusive reactive hyperaemia at the hallux was determined by laser-Doppler fluxmetry. Though time to peak flux post-occlusion almost halved following moderate intensity exercise, no outcome measure reached statistical significance (p > 0.05). These secondary findings from a randomised controlled trial are the first data reporting the effect of exercise interventions on cutaneous microvascular reactivity in the foot in people with diabetes. A period of 12 weeks of moderate-intensity or low-volume high-intensity exercise may not be enough to elicit functional improvements in foot microvascular reactivity in adults with type 2 diabetes and obesity. Larger, sufficiently powered, prospective studies are necessary to determine if additional weight loss and/or higher exercise volume is required.
Keywords
cutaneous blood flow, exercise training, laser-Doppler, microvascular reactivity, peripheral artery disease, post-occlusive reactive hyperaemia
Date
2022
Type
Journal article
Journal
Book
Volume
11
Issue
17
Page Range
1-12
Article Number
ACU Department
Research Office
Collections
Relation URI
Source URL
Event URL
Open Access Status
Published as green open access
License
CC BY 4.0
File Access
Open
Notes
© 2022 by the authors.
Licensee MDPI, Basel, Switzerland.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).