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Aging is accompanied by a blunted muscle protein synthetic response to protein ingestion
Wall, Benjamin T. Gorissen, Stefan H. M. Pennings, Bart Koopman, René Groen, Bart B. L. Verdijk, Lex B. Van Loon, Luc
Wall, Benjamin T.
Gorissen, Stefan H. M.
Pennings, Bart
Koopman, René
Groen, Bart B. L.
Verdijk, Lex B.
Van Loon, Luc
Abstract
Purpose Progressive loss of skeletal muscle mass with aging (sarcopenia) forms a global health concern. It has been suggested that an impaired capacity to increase muscle protein synthesis rates in response to protein intake is a key contributor to sarcopenia. We assessed whether differences in post-absorptive and/or post-prandial muscle protein synthesis rates exist between large cohorts of healthy young and older men. Procedures We performed a cross-sectional, retrospective study comparing in vivo post-absorptive muscle protein synthesis rates determined with stable isotope methodologies between 34 healthy young (22±1 y) and 72 older (75±1 y) men, and post-prandial muscle protein synthesis rates between 35 healthy young (22±1 y) and 40 older (74±1 y) men. Findings Post-absorptive muscle protein synthesis rates did not differ significantly between the young and older group. Post-prandial muscle protein synthesis rates were 16% lower in the older subjects when compared with the young. Muscle protein synthesis rates were > 3 fold more responsive to dietary protein ingestion in the young. Irrespective of age, there was a strong negative correlation between post-absorptive muscle protein synthesis rates and the increase in muscle protein synthesis rate following protein ingestion. Conclusions Aging is associated with the development of muscle anabolic inflexibility which represents a key physiological mechanism underpinning sarcopenia.
Keywords
Date
2015
Type
Journal article
Journal
PLoS ONE
Book
Volume
10
Issue
11
Page Range
1-13
Article Number
ACU Department
Centre for Exercise and Nutrition
Faculty of Health Sciences
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
Open access
License
File Access
Open
Notes
[http://creativecommons.org/licenses/by/4.0/]
This work is licensed under a [http://creativecommons.org/licenses/by/4.0/] Creative Commons Attribution 4.0 International License.