Loading...
Interrupting prolonged sitting and endothelial function in polycystic ovary syndrome
Taylor, Frances C. Dunstan, David W. Fletcher, Elly Townsend, Melanie K. Larsen, Robyn N. Rickards, K. Y. M. Maniar, Nirav Buman, Matthew Dempsey, Paddy C. Joham, Anju E.
Taylor, Frances C.
Dunstan, David W.
Fletcher, Elly
Townsend, Melanie K.
Larsen, Robyn N.
Rickards, K. Y. M.
Maniar, Nirav
Buman, Matthew
Dempsey, Paddy C.
Joham, Anju E.
Abstract
Purpose
In healthy adults, the impairment of vascular function associated with prolonged sitting can be mitigated with intermittent brief bouts of activity. It is unknown whether these benefits extend to women with polycystic ovary syndrome (PCOS), in whom vascular function is typically impaired and sitting time is high. We examined the acute effect of regularly interrupting sitting time with brief simple resistance activities (SRA) on vascular function in PCOS.
Methods
In a randomized crossover trial, 13 physically inactive women with PCOS (18–45 yr) completed two 3.5-h conditions: 1) uninterrupted sitting (SIT) and 2) sitting interrupted by 3-min bouts of SRA every 30 min. Femoral artery flow-mediated dilation (FMD), resting shear rate, and resting blood flow were measured at 0, 1, and 3.5 h.
Results
Mean resting femoral shear rate, averaged across the 3.5 h, significantly increased in the SRA condition relative to the SIT condition (40.1 ± 6.1 vs 62.8 ± 6.1 s−1, P < 0.0001). In addition, mean resting blood flow also significantly increased across the 3.5 h for SRA relative to SIT (45.0 ± 9.8 vs 72.8 ± 9.9 mL·min−1, P < 0.0001). There were no differences between conditions in the temporal change in femoral artery FMD across 3.5 h (Ptime–condition > 0.05 for all).
Conclusion
Frequently interrupting sitting with SRA acutely increased resting shear rate and blood flow in women with PCOS but did not alter FMD. With sedentary behavior increasing in prevalence, longer-term studies of similar interventions to reduce and break up sitting time are warranted.
Keywords
arteries, blood flow, sedentary behavior
Date
2021
Type
Journal article
Journal
Medicine & Science in Sports & Exercise
Book
Volume
53
Issue
3
Page Range
479-486
Article Number
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
School of Behavioural and Health Sciences
Faculty of Health Sciences
School of Behavioural and Health Sciences
Relation URI
Source URL
Event URL
Open Access Status
License
All rights reserved
File Access
Controlled