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The emerging potential of the apelin-APJ system in heart failure
Dalzell, Jonathan R. Rocchiccioli, John P. Weir, Robin A. P. Jackson, Colette E. Padmanabhan, Neal Gardner, Roy S. Petrie, Mark C. McMurray, John J. V.
Dalzell, Jonathan R.
Rocchiccioli, John P.
Weir, Robin A. P.
Jackson, Colette E.
Padmanabhan, Neal
Gardner, Roy S.
Petrie, Mark C.
McMurray, John J. V.
Abstract
The apelin-APJ system is a novel neurohormonal pathway, with studies to date suggesting that it may be of pathophysiologic relevance in heart failure and may indeed be a viable therapeutic target in this syndrome. This interest is driven primarily by the demonstration of its vasodilator, inotropic, and aquaretic actions as well as its apparent antagonistic relationship with the renin-angiotensin system. However, its promise is heightened further by the observation that, unlike other and more established cardioprotective pathways, it appears to be down-regulated in heart failure, suggesting that augmentation of this axis may have a powerful effect on the heart failure syndrome. We review the literature regarding the apelin-APJ system in heart failure and suggest areas requiring further research.
Keywords
apelin, APJ, heart failure, neurohormone, pathophysiology
Date
2015
Type
Journal article
Journal
Journal of Cardiac Failure
Book
Volume
21
Issue
6
Page Range
489-498
Article Number
ACU Department
Collections
Relation URI
Source URL
Event URL
Open Access Status
License
File Access
Controlled