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Quality of life after fragility fracture in the Russian Federation : Results from the Russian arm of the International Cost and Utility Related to Osteoporotic Fractures Study (ICUROS)
Lesnyak, Olga Svedbom, Axel Belova, Ksenia Dobrovolskaya, Olga Ershova, Olga Golubev, Georgij Grebenshikov, Vyacheslav Ivanov, Sergej Kochish, Alexander Menshikova, Larissa
Lesnyak, Olga
Svedbom, Axel
Belova, Ksenia
Dobrovolskaya, Olga
Ershova, Olga
Golubev, Georgij
Grebenshikov, Vyacheslav
Ivanov, Sergej
Kochish, Alexander
Menshikova, Larissa
Author
Lesnyak, Olga
Svedbom, Axel
Belova, Ksenia
Dobrovolskaya, Olga
Ershova, Olga
Golubev, Georgij
Grebenshikov, Vyacheslav
Ivanov, Sergej
Kochish, Alexander
Menshikova, Larissa
Nikitinskaya, Oxana
Nurligayanov, Radik
Solodovnikov, Alexander
Toroptsova, Natalia
Varavko, Julia
Zotkin, Eugenij
Borgstrom, Fredrik
Kanis, John A.
Svedbom, Axel
Belova, Ksenia
Dobrovolskaya, Olga
Ershova, Olga
Golubev, Georgij
Grebenshikov, Vyacheslav
Ivanov, Sergej
Kochish, Alexander
Menshikova, Larissa
Nikitinskaya, Oxana
Nurligayanov, Radik
Solodovnikov, Alexander
Toroptsova, Natalia
Varavko, Julia
Zotkin, Eugenij
Borgstrom, Fredrik
Kanis, John A.
Abstract
Summary
Changes in health-related quality of life (QoL) due to hip, humeral, ankle, spine, and distal forearm fracture were measured in Russian adults age 50 years or more over the first 18 months after fracture. The accumulated mean QoL loss after hip fracture was 0.5 and significantly greater than after fracture of the distal forearm (0.13), spine (0.21), proximal humerus (0.26), and ankle (0.27).
Introduction
Data on QoL following osteoporotic fractures in Russia are scarce. The present study evaluated the impact of hip, vertebral, proximal humerus, distal forearm, and ankle fracture up to 18 months after fracture from the Russian arm of the International Costs and Utilities Related to Osteoporotic Fractures Study.
Methods
Individuals age ≥ 50 years with low-energy-induced humeral, hip, clinical vertebral, ankle, or distal forearm fracture were enrolled. After a recall of pre-fracture status, HRQoL was prospectively collected over 18 months of follow-up using EQ-5D-3L. Multivariate regression analysis was used to identify determinants of QALYs loss.
Results
At 2 weeks, patients with hip fracture (n = 223) reported the lowest mean health state utility value (HSUV) compared with other fracture sites. Thereafter, utility values increased but remained significantly lower than before fracture. For spine (n = 183), humerus (n = 166), and ankle fractures (n = 214), there was a similar pattern of disutility with a nadir within 2 weeks and a progressive recovery thereafter. The accumulated mean QoL loss after hip fracture was 0.5 and significantly greater than after fracture of the distal forearm (0.13), spine (0.21), proximal humerus (0.26), and ankle (0.27). Substantial impairment in self-care and usual activities immediately after fracture were important predictors of recovery across at all fracture sites.
Conclusions
Fractures of the hip, vertebral, distal forearm, ankle, and proximal humerus incur substantial loss of QoL in Russia. The utility values derived from this study can be used in future economic evaluations.
Keywords
hip fracture, ankle fracture, vertebral fracture, distal forearm fracture, humerus fracture, ICUROS, osteoporosis, quality of life
Date
2020
Type
Journal article
Journal
Archives of Osteoporosis
Book
Volume
15
Issue
1
Page Range
1-9
Article Number
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
Published as ‘gold’ (paid) open access
License
CC BY 4.0
File Access
Open