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White matter alterations in adults with probable developmental coordination disorder: An MRI diffusion tensor imaging study
Williams, Jacqueline Kashuk, Saman R. Wilson, Peter H. Thorpe, Graham Egan, Gary F.
Williams, Jacqueline
Kashuk, Saman R.
Wilson, Peter H.
Thorpe, Graham
Egan, Gary F.
Abstract
Movement skill difficulties in children [or developmental coordination disorder (DCD)] often persist into adulthood (in up to 70% of cases). The suggestion of white matter microstructure alterations in children with DCD raises the question of whether similar alterations are present in adults with probable DCD (pDCD). Twelve adults with pDCD and 11 adults without pDCD underwent diffusion tensor imaging. The results showed that the pDCD group had significantly lower fractional anisotropy in the corticospinal tract and superior longitudinal fasciculus and lower mean diffusivity in the internal capsule and inferior longitudinal fasciculus. This suggests reduced white matter integrity in parietofrontal and corticospinal tracts, with possible compensatory increases in white matter integrity along the visual ventral stream and front-occipital networks. These findings support recent neuroimaging studies in children with DCD and suggest persistent neurobiological alterations along white matter tracts that are known to support motor planning, cognition and their association.
Keywords
developmental coordination disorder, diffusion tensor imaging, motor skill disorders, white matter
Date
2017
Type
Journal article
Journal
NeuroReport
Book
Volume
28
Issue
2
Page Range
87-92
Article Number
ACU Department
School of Behavioural and Health Sciences
Faculty of Health Sciences
Faculty of Health Sciences
Relation URI
Source URL
Event URL
Open Access Status
License
File Access
Controlled