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The incidence of a first major osteoporotic fracture in Iceland and implications for FRAX
Siggeirsdottir, K. Aspelund, T. Johansson, Helena Gudmundsson, E. F. Mogensen, B. Jonsson, B. Y. Gudnason, V. McCloskey, Eugene Oden, Anders Sigurdsson, G.
Siggeirsdottir, K.
Aspelund, T.
Johansson, Helena
Gudmundsson, E. F.
Mogensen, B.
Jonsson, B. Y.
Gudnason, V.
McCloskey, Eugene
Oden, Anders
Sigurdsson, G.
Abstract
Summary Based on an extensive cohort study over 25 years, the present study supports the assumption that major osteoporotic fractures can be reasonably predicted from hip fracture rates. Introduction The construct for FRAX models depends on algorithms to adjust for double counting of fracture outcomes in some models and in others, to estimate the incidence of a major fracture from hip fracture rates. The aim of the present study was to test the validity of these algorithms in a large prospective cohort. Methods The incidence of hip, clinical spine, distal forearm, and humerus fracture was determined in the prospective and ongoing population-based Reykjavik Study with follow up of 257,001 person-years. The incidence of a first major fracture was compared with the correction factors used in FRAX to adjust the incidence of several fracture outcomes for double counting. In addition, the incidence of a major osteoporotic fracture estimated from the Icelandic hip fracture rates was compared with the Malmo ratios used in FRAX. Results The adjustments necessary to account for multiple fracture outcomes were similar to those previously derived from Sweden. Additionally, incidence of a first major osteoporotic fracture was similar to that derived for FRAX models. Conclusion The findings of the present study support the algorithms used in FRAX to estimate the incidence of a first major fracture and the predictive value of hip fracture for other major fractures.
Keywords
Fracture incidence, FRAX, Major osteoporotic fracture
Date
2014
Type
Journal article
Journal
Osteoporosis International
Book
Volume
25
Issue
10
Page Range
2445-2451
Article Number
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
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Open Access Status
License
File Access
Controlled