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Exploring the relationship between β-adrenergic receptor kinase-1 and physical symptoms in heart failure
Denfeld, Quin E. Mudd, James O. Hasan, Wohaib Gelow, Jill M. Hiatt, Shirin O. Winters-Stone, Kerri Lee, Christopher S.
Denfeld, Quin E.
Mudd, James O.
Hasan, Wohaib
Gelow, Jill M.
Hiatt, Shirin O.
Winters-Stone, Kerri
Lee, Christopher S.
Abstract
Background
The relationship between physical heart failure (HF) symptoms and pathophysiological mechanisms is unclear.
Objective
To quantify the relationship between plasma β-adrenergic receptor kinase-1 (βARK1) and physical symptoms among adults with HF.
Methods
We performed a secondary analysis of data collected from two studies of adults with HF. Plasma βARK1 was quantified using an enzyme-linked immunosorbent assay. Physical symptoms were measured with the HF Somatic Perception Scale (HFSPS). Generalized linear modeling was used to quantify the relationship between βARK1 and HFSPS scores.
Results
The average age (n = 94) was 54.5 ± 13.1 years, 76.6% were male, and a majority (83.0%) had Class III or IV HF. βARK1 was significantly associated with HFSPS scores (β = 0.22 ± 0.10, p = 0.038), adjusting for other predictors of physical symptoms (model R2 = 0.250, F(7, 70) = 3.34, p = 0.004).
Conclusions
Higher βARK1 is associated with worse physical HF symptoms, pinpointing a potential pathophysiologic underpinning.
Keywords
heart failure, symptom, biomarkers, beta-adrenergic receptor kinases, G protein-coupled receptor kinase-2
Date
2018
Type
Journal article
Journal
Heart and Lung
Book
Volume
47
Issue
4
Page Range
281-284
Article Number
ACU Department
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
License
All rights reserved
File Access
Controlled