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Quality of life after hip, vertebral, and distal forearm fragility fractures measured using the EQ-5D-3L, EQ-VAS, and time-trade-off: results from the ICUROS
Svedbom, A. Borgström, Fredrik Hernlund, E. Ström, O. Alekna, V. Bianchi, Maria L. Clark, P. Curiel, M. D. Dimai, Hans P. Jürisson, M.
Svedbom, A.
Borgström, Fredrik
Hernlund, E.
Ström, O.
Alekna, V.
Bianchi, Maria L.
Clark, P.
Curiel, M. D.
Dimai, Hans P.
Jürisson, M.
Author
Svedbom, A.
Borgström, Fredrik
Hernlund, E.
Ström, O.
Alekna, V.
Bianchi, Maria L.
Clark, P.
Curiel, M. D.
Dimai, Hans P.
Jürisson, M.
Uusküla, A.
Lember, M.
Kallikorm, R.
Lesnyak, Olga
McCloskey, Eugene
Ershova, Olga
Sanders, Kerrie
Silverman, S.
Tamulaitiene, M.
Thomas, T.
Tosteson, Anna N.A.
Jönsson, B.
Kanis, John
Borgström, Fredrik
Hernlund, E.
Ström, O.
Alekna, V.
Bianchi, Maria L.
Clark, P.
Curiel, M. D.
Dimai, Hans P.
Jürisson, M.
Uusküla, A.
Lember, M.
Kallikorm, R.
Lesnyak, Olga
McCloskey, Eugene
Ershova, Olga
Sanders, Kerrie
Silverman, S.
Tamulaitiene, M.
Thomas, T.
Tosteson, Anna N.A.
Jönsson, B.
Kanis, John
Abstract
Introduction: The International Costs and Utilities Related to Osteoporotic fractures Study is a multinational observational study set up to describe the costs and quality of life (QoL) consequences of fragility fracture. This paper aims to estimate and compare QoL after hip, vertebral, and distal forearm fracture using time-trade-off (TTO), the EuroQol (EQ) Visual Analogue Scale (EQ-VAS), and the EQ-5D-3L valued using the hypothetical UK value set. Methods: Data were collected at four time-points for five QoL point estimates: within 2 weeks after fracture (including prefracture recall), and at 4, 12, and 18 months after fracture. Health state utility values (HSUVs) were derived for each fracture type and time-point using the three approaches (TTO, EQ-VAS, EQ-5D-3L). HSUV were used to estimate accumulated QoL loss and QoL multipliers. Results: In total, 1410 patients (505 with hip, 316 with vertebral, and 589 with distal forearm fracture) were eligible for analysis. Across all time-points for the three fracture types, TTO provided the highest HSUVs, whereas EQ-5D-3L consistently provided the lowest HSUVs directly after fracture. Except for 13–18 months after distal forearm fracture, EQ-5D-3L generated lower QoL multipliers than the other two methods, whereas no equally clear pattern was observed between EQ-VAS and TTO. On average, the most marked differences between the three approaches were observed immediately after the fracture. Conclusions: The approach to derive QoL markedly influences the estimated QoL impact of fracture. Therefore the choice of approach may be important for the outcome and interpretation of cost-effectiveness analysis of fracture prevention.
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Date
2017
Type
Journal article
Journal
Quality of Life Research
Book
Volume
27
Issue
3
Page Range
707-716
Article Number
ACU Department
School of Allied Health
Faculty of Health Sciences
School of Arts
Faculty of Education and Arts
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
School of Arts
Faculty of Education and Arts
Mary MacKillop Institute for Health Research
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