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Hitting the sweet spot : A systematic review of the bioactivity and health benefits of phenolic glycosides from medicinally used plants
Johnson, Joel B. Mani, Janice S. Broszczak, Daniel Prasad, Shirtika S. Ekanayake, Charitha P. Strappe, Padraig Valeris, Peter Naiker, Mani
Johnson, Joel B.
Mani, Janice S.
Broszczak, Daniel
Prasad, Shirtika S.
Ekanayake, Charitha P.
Strappe, Padraig
Valeris, Peter
Naiker, Mani
Abstract
Phenolic acid and flavonoid glycosides form a varied class of naturally occurring compounds, characterised by high polarity—resulting from the glycone moiety—and the presence of multiple phenol functionalities, which often leads to strong antioxidant activity. Phenolic glycosides, and in particular flavonoid glycosides, may possess strong bioactive properties with broad spectrum activity. This systematic literature review provides a detailed overview of 28 studies examining the biological activity of phenolic and flavonoid glycosides from plant sources, highlighting the potential of these compounds as therapeutic agents. The activity of glycosides depends upon the biological activity type, identity of the aglycone and the identity and specific location of the glycone moiety. From studies reporting the activity of both glycosides and their respective aglycones, phenolic glycosides appear to generally be a storage/reserve pool of precursors of more bioactive compounds. The glycosylated compounds are likely to be more bioavailable compared to their aglycone forms, due to the presence of the sugar moieties. Hydrolysis of the glycoside in the in vivo environment would release the free aglycone, potentiating their biological activity. However, further high-quality studies are needed to firmly establish the clinical efficacy of glycosides from many of the plant species studied.
Keywords
bioactive compounds, flavonoids, glycosides, phenolics
Date
2021
Type
Journal article
Journal
Phytotherapy Research
Book
Volume
35
Issue
7
Page Range
3484-3508
Article Number
ACU Department
Collections
Relation URI
DOI
Source URL
Event URL
Open Access Status
License
All rights reserved
File Access
Controlled