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Germline variation at 8q24 and prostate cancer risk in men of European ancestry
Matejcic, Marco Saunders, Edward J. Dadaev, Tokhir Brook, Mark N. Wang, Kan Sheng, Xin Olama, Ali Amin Al Schumacher, Fredrick R. Ingles, Sue A. Govindasami, Koveela
Matejcic, Marco
Saunders, Edward J.
Dadaev, Tokhir
Brook, Mark N.
Wang, Kan
Sheng, Xin
Olama, Ali Amin Al
Schumacher, Fredrick R.
Ingles, Sue A.
Govindasami, Koveela
Author
Matejcic, Marco
Saunders, Edward J.
Dadaev, Tokhir
Brook, Mark N.
Wang, Kan
Sheng, Xin
Olama, Ali Amin Al
Schumacher, Fredrick R.
Ingles, Sue A.
Govindasami, Koveela
Benlloch, Sara
Berndt, Sonja I.
Albanes, Demetrius
Koutros, Stella
Muir, Kenneth
Stevens, Victoria L.
Gapstur, Susan M.
Tangen, Catherine M.
Batra, Jyotsna
Clements, Judith
Grönberg, Henrik
Pashayan, Nora
Schleutker, Johanna
Wolk, Alicja
West, Catharine
Mucci, Lorelei
Kraft, Peter
Cancel-Tassin, Géraldine
Sorensen, Karina D.
Maehle, Lovise
Grindedal, Eli M.
Strom, Sara S.
Neal, David E.
Hamdy, Freddie C.
Donovan, Jenny L.
Travis, Ruth C.
Hamilton, Robert J.
Rosenstein, Barry
Lu, Yong-Jie
Giles, Graham G.
Kibel, Adam S.
Vega, Ana
Bensen, Jeanette T.
Kogevinas, Manolis
Penney, Kathryn L.
Park, Jong Y.
Stanford, Janet L.
Cybulski, Cezary
Nordestgaard, Børge G.
Brenner, Hermann
Maier, Christiane
Kim, Jeri
Teixeira, Manuel R.
Neuhausen, Susan L.
De Ruyck, Kim
Razack, Azad
Newcomb, Lisa F.
Lessel, Davor
Kaneva, Radka
Usmani, Nawaid
Claessens, Frank
Townsend, Paul A.
Gago-Dominguez, Manuela
Roobol, Monique J.
Menegaux, Florence
Khaw, Kay-Tee
Cannon-Albright, Lisa A.
Pandha, Hardev
Thibodeau, Stephen N.
Schaid, Daniel J.
Henderson, Brian E.
Stern, Mariana C.
Thwaites, Alison
Guy, Michelle
Whitmore, Ian
Morgan, Angela
Fisher, Cyril
Hazel, Steve
Livni, Naomi
Cook, Margaret
Fachal, Laura
Weinstein, Stephanie
Beane Freeman, Laura E.
Hoover, Robert N.
Machiela, Mitchell J.
Lophatananon, Artitaya
Carter, Brian D.
Goodman, Phyllis J.
Moya, Leire
Srinivasan, Srilakshmi
Kedda, Mary-Anne
Yeadon, Trina
Eckert, Allison
Eklund, Martin
Cavalli-Bjoerkman, Carin
Dunning, Alison M.
Sipeky, Csilla
Hakansson, Niclas
Elliott, Rebecca
Ranu, Hardeep
Giovannucci, Edward
Turman, Constance
Hunter, David J.
Cussenot, Olivier
Orntoft, Torben Falck
Lane, Athene
Lewis, Sarah J.
Davis, Michael
Key, Tim J.
Brown, Paul
Kulkarni, Girish S.
Zlotta, Alexandre R.
Fleshner, Neil E.
Finelli, Antonio
Mao, Xueying
Marzec, Jacek
MacInnis, Robert J.
Milne, Roger
Hopper, John L.
Aguado, Miguel
Bustamante, Mariona
Castaño-Vinyals, Gemma
Gracia-Lavedan, Esther
Cecchini, Lluís
Stampfer, Meir
Ma, Jing
Sellers, Thomas A.
Geybels, Milan S.
Park, Hyun
Zachariah, Babu
Kolb, Suzanne
Wokolorczyk, Dominika
Lubinski, Jan
Kluzniak, Wojciech
Nielsen, Sune F.
Weisher, Maren
Cuk, Katarina
Vogel, Walther
Luedeke, Manuel
Logothetis, Christopher J. J.
Paulo, Paula
Cardoso, Marta
Maia, Sofia
Silva, Maria P.
Steele, Linda
Ding, Yuan Chun
De Meerleer, Gert
De Langhe, Sofie
Thierens, Hubert
Lim, Jasmine
Tan, Meng H.
Ong, Aik T.
Lin, Daniel W.
Kachakova, Darina
Mitkova, Atanaska
Mitev, Vanio
Parliament, Matthew
Jenster, Guido
Bangma, Christopher
Schroder, F. H.
Truong, Thérèse
Koudou, Yves Akoli
Michael, Agnieszka
Kierzek, Andrzej
Karlsson, Ami
Broms, Michael
Wu, Huihai
Aukim-Hastie, Claire
Tillmans, Lori
Riska, Shaun
McDonnell, Shannon K.
Dearnaley, David
Spurdle, Amanda
Gardiner, Robert
Hayes, Vanessa
Butler, Lisa
Taylor, Renea
Papargiris, Melissa
Saunders, Pamela
Kujala, Paula
Talala, Kirsi
Taari, Kimmo
Bentzen, Søren
Hicks, Belynda
Vogt, Aurelie
Hutchinson, Amy
Cox, Angela
George, Anne
Toi, Ants
Evans, Andrew
van der Kwast, Theodorus H.
Imai, Takashi
Saito, Shiro
Zhao, Shan-Chao
Ren, Guoping
Zhang, Yangling
Yu, Yongwei
Wu, Yudong
Wu, Ji
Zhou, Bo
Pedersen, John
Lobato-Busto, Ramón
Ruiz-Dominguez, José Manuel
Mengual, Lourdes
Alcaraz, Antonio
Pow-Sang, Julio
Herkommer, Kathleen
Vlahova, Aleksandrina
Dikov, Tihomir
Christova, Svetlana
Carracedo, Angel
Tretarre, Brigitte
Rebillard, Xavier
Mulot, Claire
Adolfsson, Jan
Stattin, Par
Johansson, Jan-Erik
Martin, Richard M.
Thompson, Ian M.
Chambers, Suzanne
Aitken, Joanne
Horvath, Lisa
Haynes, Anne-Maree
Tilley, Wayne
Risbridger, Gail
Aly, Markus
Nordström, Tobias
Pharoah, Paul
Tammela, Teuvo L. J.
Murtola, Teemu
Auvinen, Anssi
Burnet, Neil
Barnett, Gill
Andriole, Gerald
Klim, Aleksandra
Drake, Bettina F.
Borre, Michael
Kerns, Sarah
Ostrer, Harry
Zhang, Hong-Wei
Cao, Guangwen
Lin, Ji
Ling, Jin
Li, Meiling
Feng, Ninghan
Li, Jie
He, Weiyang
Guo, Xin
Sun, Zan
Wang, Guomin
Guo, Jianming
Southey, Melissa C.
Fitzgerald, Liesel M.
Marsden, Gemma
Gómez-Caamaño, Antonio
Carballo, Ana
Peleteiro, Paula
Calvo, Patricia
Szulkin, Robert
Llorca, Javier
Dierssen-Sotos, Trinidad
Gómez Acebo, Inés
Lin, Hui-Yi
Ostrander, Elaine A.
Bisbjerg, Rasmus
Klarskov, Peter
Røder, Martin Andreas
Iversen, Peter
Holleczek, Bernd
Stegmaier, Christa
Schnoeller, Thomas
Bohnert, Philipp
John, Esther M.
Ost, Piet
Teo, Soo-Hwang
Gamulin, Marija
Kulis, Tomislav
Kastelan, Zeljko
Slavov, Chavdar
Popov, Elenko
Van den Broeck, Thomas
Joniau, Steven
Larkin, Samantha
Castelao, Jose Esteban
Martinez, Maria Elena
van Schaik, Ron H. N.
Xu, Jianfeng
Lindström, Sara
Riboli, Elio
Berry, Clare
Siddiq, Afshan
Canzian, Federico
Kolonel, Laurence N.
Le Marchand, Loic
Freedman, Matthew
Cenee, Sylvie
Sanchez, Marie
Wiklund, Fredrik
Chanock, Stephen J.
Easton, Douglas F.
Eeles, Rosalind A.
Kote-Jarai, Zsofia
Conti, David V.
Haiman, Christopher A.
Saunders, Edward J.
Dadaev, Tokhir
Brook, Mark N.
Wang, Kan
Sheng, Xin
Olama, Ali Amin Al
Schumacher, Fredrick R.
Ingles, Sue A.
Govindasami, Koveela
Benlloch, Sara
Berndt, Sonja I.
Albanes, Demetrius
Koutros, Stella
Muir, Kenneth
Stevens, Victoria L.
Gapstur, Susan M.
Tangen, Catherine M.
Batra, Jyotsna
Clements, Judith
Grönberg, Henrik
Pashayan, Nora
Schleutker, Johanna
Wolk, Alicja
West, Catharine
Mucci, Lorelei
Kraft, Peter
Cancel-Tassin, Géraldine
Sorensen, Karina D.
Maehle, Lovise
Grindedal, Eli M.
Strom, Sara S.
Neal, David E.
Hamdy, Freddie C.
Donovan, Jenny L.
Travis, Ruth C.
Hamilton, Robert J.
Rosenstein, Barry
Lu, Yong-Jie
Giles, Graham G.
Kibel, Adam S.
Vega, Ana
Bensen, Jeanette T.
Kogevinas, Manolis
Penney, Kathryn L.
Park, Jong Y.
Stanford, Janet L.
Cybulski, Cezary
Nordestgaard, Børge G.
Brenner, Hermann
Maier, Christiane
Kim, Jeri
Teixeira, Manuel R.
Neuhausen, Susan L.
De Ruyck, Kim
Razack, Azad
Newcomb, Lisa F.
Lessel, Davor
Kaneva, Radka
Usmani, Nawaid
Claessens, Frank
Townsend, Paul A.
Gago-Dominguez, Manuela
Roobol, Monique J.
Menegaux, Florence
Khaw, Kay-Tee
Cannon-Albright, Lisa A.
Pandha, Hardev
Thibodeau, Stephen N.
Schaid, Daniel J.
Henderson, Brian E.
Stern, Mariana C.
Thwaites, Alison
Guy, Michelle
Whitmore, Ian
Morgan, Angela
Fisher, Cyril
Hazel, Steve
Livni, Naomi
Cook, Margaret
Fachal, Laura
Weinstein, Stephanie
Beane Freeman, Laura E.
Hoover, Robert N.
Machiela, Mitchell J.
Lophatananon, Artitaya
Carter, Brian D.
Goodman, Phyllis J.
Moya, Leire
Srinivasan, Srilakshmi
Kedda, Mary-Anne
Yeadon, Trina
Eckert, Allison
Eklund, Martin
Cavalli-Bjoerkman, Carin
Dunning, Alison M.
Sipeky, Csilla
Hakansson, Niclas
Elliott, Rebecca
Ranu, Hardeep
Giovannucci, Edward
Turman, Constance
Hunter, David J.
Cussenot, Olivier
Orntoft, Torben Falck
Lane, Athene
Lewis, Sarah J.
Davis, Michael
Key, Tim J.
Brown, Paul
Kulkarni, Girish S.
Zlotta, Alexandre R.
Fleshner, Neil E.
Finelli, Antonio
Mao, Xueying
Marzec, Jacek
MacInnis, Robert J.
Milne, Roger
Hopper, John L.
Aguado, Miguel
Bustamante, Mariona
Castaño-Vinyals, Gemma
Gracia-Lavedan, Esther
Cecchini, Lluís
Stampfer, Meir
Ma, Jing
Sellers, Thomas A.
Geybels, Milan S.
Park, Hyun
Zachariah, Babu
Kolb, Suzanne
Wokolorczyk, Dominika
Lubinski, Jan
Kluzniak, Wojciech
Nielsen, Sune F.
Weisher, Maren
Cuk, Katarina
Vogel, Walther
Luedeke, Manuel
Logothetis, Christopher J. J.
Paulo, Paula
Cardoso, Marta
Maia, Sofia
Silva, Maria P.
Steele, Linda
Ding, Yuan Chun
De Meerleer, Gert
De Langhe, Sofie
Thierens, Hubert
Lim, Jasmine
Tan, Meng H.
Ong, Aik T.
Lin, Daniel W.
Kachakova, Darina
Mitkova, Atanaska
Mitev, Vanio
Parliament, Matthew
Jenster, Guido
Bangma, Christopher
Schroder, F. H.
Truong, Thérèse
Koudou, Yves Akoli
Michael, Agnieszka
Kierzek, Andrzej
Karlsson, Ami
Broms, Michael
Wu, Huihai
Aukim-Hastie, Claire
Tillmans, Lori
Riska, Shaun
McDonnell, Shannon K.
Dearnaley, David
Spurdle, Amanda
Gardiner, Robert
Hayes, Vanessa
Butler, Lisa
Taylor, Renea
Papargiris, Melissa
Saunders, Pamela
Kujala, Paula
Talala, Kirsi
Taari, Kimmo
Bentzen, Søren
Hicks, Belynda
Vogt, Aurelie
Hutchinson, Amy
Cox, Angela
George, Anne
Toi, Ants
Evans, Andrew
van der Kwast, Theodorus H.
Imai, Takashi
Saito, Shiro
Zhao, Shan-Chao
Ren, Guoping
Zhang, Yangling
Yu, Yongwei
Wu, Yudong
Wu, Ji
Zhou, Bo
Pedersen, John
Lobato-Busto, Ramón
Ruiz-Dominguez, José Manuel
Mengual, Lourdes
Alcaraz, Antonio
Pow-Sang, Julio
Herkommer, Kathleen
Vlahova, Aleksandrina
Dikov, Tihomir
Christova, Svetlana
Carracedo, Angel
Tretarre, Brigitte
Rebillard, Xavier
Mulot, Claire
Adolfsson, Jan
Stattin, Par
Johansson, Jan-Erik
Martin, Richard M.
Thompson, Ian M.
Chambers, Suzanne
Aitken, Joanne
Horvath, Lisa
Haynes, Anne-Maree
Tilley, Wayne
Risbridger, Gail
Aly, Markus
Nordström, Tobias
Pharoah, Paul
Tammela, Teuvo L. J.
Murtola, Teemu
Auvinen, Anssi
Burnet, Neil
Barnett, Gill
Andriole, Gerald
Klim, Aleksandra
Drake, Bettina F.
Borre, Michael
Kerns, Sarah
Ostrer, Harry
Zhang, Hong-Wei
Cao, Guangwen
Lin, Ji
Ling, Jin
Li, Meiling
Feng, Ninghan
Li, Jie
He, Weiyang
Guo, Xin
Sun, Zan
Wang, Guomin
Guo, Jianming
Southey, Melissa C.
Fitzgerald, Liesel M.
Marsden, Gemma
Gómez-Caamaño, Antonio
Carballo, Ana
Peleteiro, Paula
Calvo, Patricia
Szulkin, Robert
Llorca, Javier
Dierssen-Sotos, Trinidad
Gómez Acebo, Inés
Lin, Hui-Yi
Ostrander, Elaine A.
Bisbjerg, Rasmus
Klarskov, Peter
Røder, Martin Andreas
Iversen, Peter
Holleczek, Bernd
Stegmaier, Christa
Schnoeller, Thomas
Bohnert, Philipp
John, Esther M.
Ost, Piet
Teo, Soo-Hwang
Gamulin, Marija
Kulis, Tomislav
Kastelan, Zeljko
Slavov, Chavdar
Popov, Elenko
Van den Broeck, Thomas
Joniau, Steven
Larkin, Samantha
Castelao, Jose Esteban
Martinez, Maria Elena
van Schaik, Ron H. N.
Xu, Jianfeng
Lindström, Sara
Riboli, Elio
Berry, Clare
Siddiq, Afshan
Canzian, Federico
Kolonel, Laurence N.
Le Marchand, Loic
Freedman, Matthew
Cenee, Sylvie
Sanchez, Marie
Wiklund, Fredrik
Chanock, Stephen J.
Easton, Douglas F.
Eeles, Rosalind A.
Kote-Jarai, Zsofia
Conti, David V.
Haiman, Christopher A.
Abstract
Chromosome 8q24 is a susceptibility locus for multiple cancers, including prostate cancer. Here we combine genetic data across the 8q24 susceptibility region from 71,535 prostate cancer cases and 52,935 controls of European ancestry to define the overall contribution of germline variation at 8q24 to prostate cancer risk. We identify 12 independent risk signals for prostate cancer (p < 4.28 × 10−15), including three risk variants that have yet to be reported. From a polygenic risk score (PRS) model, derived to assess the cumulative effect of risk variants at 8q24, men in the top 1% of the PRS have a 4-fold (95%CI = 3.62–4.40) greater risk compared to the population average. These 12 variants account for ~25% of what can be currently explained of the familial risk of prostate cancer by known genetic risk factors. These findings highlight the overwhelming contribution of germline variation at 8q24 on prostate cancer risk which has implications for population risk stratification.
Keywords
Date
2018
Type
Journal article
Journal
Nature Communications
Book
Volume
9
Issue
1
Page Range
1-11
Article Number
Article 4616
ACU Department
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
Published as ‘gold’ (paid) open access
License
CC BY 4.0
File Access
Open