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Circadian rest/activity rhythms as predictors of mood in a small sample of outpatients with bipolar disorder
Bullock, Ben Murray, Greg Van Someren, Eus J. W. Judd, Fiona
Bullock, Ben
Murray, Greg
Van Someren, Eus J. W.
Judd, Fiona
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Abstract
Circadian rhythm disturbance is believed to play a role in the pathogenesis of bipolar disorder. The aim of the current pilot study was to investigate the clinically significant hypothesis that the circadian activity rhythm may be associated with daily mood in bipolar disorder. It was hypothesized that decreased amplitude of the circadian activity rhythm would be associated with lowered daily mood. Six outpatients diagnosed with bipolar disorder were followed prospectively for between 63 and 177 consecutive days. The 24-hour rest/activity rhythm was measured continuously using actigraphy and participants rated their mood daily via a validated software interface (ChronoRecord). Concomitant time series analysis between input (amplitude of the rest/activity rhythm) and output (mood) series’ using the Box-Jenkins ARIMA methodology found predicted positive associations between the two series’ in each case, although the association reached significance in only one time series. The clinical significance of this trend is discussed.
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Date
2008
Type
Conference paper
Journal
Book
Proceedings of 43rd APS annual conference 23 - 27 September 2008, Hobart, Tasmania : Psychology leading change
Volume
Issue
Page Range
61-65
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ACU Department
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Open Access Status
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All rights reserved
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