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Dietary Vitamin K1 intake is associated with lower long-term fracture-related hospitalization risk : The Perth longitudinal study of ageing women
Sim, Marc Strydom, Andre Blekkenhorst, Lauren C. Bondonno, Nicola P. McCormick, Rachel Lim, Wai H. Zhu, Kun Byrnes, Elizabeth Hodgson, Jonathan M. Lewis, Joshua R.
Sim, Marc
Strydom, Andre
Blekkenhorst, Lauren C.
Bondonno, Nicola P.
McCormick, Rachel
Lim, Wai H.
Zhu, Kun
Byrnes, Elizabeth
Hodgson, Jonathan M.
Lewis, Joshua R.
Abstract
This study examined the association between dietary Vitamin K1 intake with fracture-related hospitalizations over 14.5 years in community-dwelling older Australian women (n = 1373, ≥70 years). Dietary Vitamin K1 intake at baseline (1998) was estimated using a validated food frequency questionnaire and a new Australian Vitamin K nutrient database, which was supplemented with published data. Over 14.5 years, any fracture (n = 404, 28.3%) and hip fracture (n = 153, 10.7%) related hospitalizations were captured using linked health data. Plasma Vitamin D status (25OHD) and the ratio of undercarboxylated osteocalcin (ucOC) to total osteocalcin (tOC) from serum was assessed at baseline. Estimates of dietary Vitamin K1 intake were supported by a significant inverse association with ucOC : tOC; a marker of Vitamin K status (r = −0.12, p < 0.001). Compared to women with the lowest Vitamin K1 intake (Quartile 1, <61 μg d−1), women with the highest Vitamin K1 intake (Quartile 4, ≥99 μg d−1) had lower hazards for any fracture- (HR 0.69 95%CI 0.52–0.91, p < 0.001) and hip fracture-related hospitalization (HR 0.51 95%CI 0.32–0.79, p < 0.001), independent of 25OHD levels, as part of multivariable-adjusted analysis. Spline analysis suggested a nadir in the relative hazard for any fracture-related hospitalizations at a Vitamin K1 intake of approximately 100 μg day−1. For hip fractures, a similar relationship was apparent. Higher dietary Vitamin K1 is associated with lower long-term risk for any fracture- and hip fracture-related hospitalizations in community-dwelling older women.
Keywords
Date
2022
Type
Journal article
Journal
Food and Function
Book
Volume
13
Issue
20
Page Range
10642-10650
Article Number
ACU Department
Collections
Relation URI
Source URL
Event URL
Open Access Status
License
All rights reserved
File Access
Controlled