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Physical activity, family history of diabetes and risk of developing hyperglycaemia and diabetes among adults in Mainland China
Xu, Fei Wang, Youfa Ware, Robert Ah Tse, Lapah Dunstan, David Liang, Yaqiong Wang, Zhiyong Hong, Xin Owen, Neville
Xu, Fei
Wang, Youfa
Ware, Robert
Ah Tse, Lapah
Dunstan, David
Liang, Yaqiong
Wang, Zhiyong
Hong, Xin
Owen, Neville
Abstract
Aims: To investigate the joint influence of physical activity and family history of diabetes on the subsequent risk of developing hyperglycaemia and Type 2 diabetes among Chinese adults. Methods: A prospective community-based cohort study was conducted among adults aged 35 years and older during 2004–2007 in Nanjing, China. Four communities (three urban and one rural) were randomly selected from 11 urban districts and two rural counties. Hyperglycaemia and Type 2 diabetes were defined using World Health Organization criteria based on fasting blood glucose concentration and physicians’ diagnosis, respectively. Physical activity, parental diabetes history, and other important covariates were assessed at baseline and in the third-year follow-up survey. Results: At study conclusion data were collected from 3031 participants (follow-up rate 81.3%). The 3-year cumulative incidence of hyperglycaemia and Type 2 diabetes was 6.2% and 2.4%, respectively. After adjustment for potential confounding variables, compared with those with positive family history and insufficient physical activity, the adjusted relative risk ratio (95% CI) of developing hyperglycaemia was 0.19 (0.02, 1.51) for participants with sufficient physical activity and a positive family history; 0.55 (0.31, 0.97) for participants with insufficient physical activity and a negative family history; and 0.36 (0.19, 0.70) for participants with sufficient physical activity but a negative family history. Participants who had a negative family history and insufficient physical activity were also less likely to develop Type 2 diabetes (RRR = 0.28; 0.14, 0.54), and participants with a negative family history and sufficient physical activity were the least likely to develop Type 2 diabetes (0.23; 0.10, 0.56). Conclusions: Sufficient physical activity and negative family history of diabetes may jointly reduce the risk of developing hyperglycaemia and Type 2 diabetes in Chinese adults.
Keywords
Date
2012
Type
Journal article
Journal
Diabetic Medicine
Book
Volume
29
Issue
5
Page Range
593-599
Article Number
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
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Relation URI
Source URL
Event URL
Open Access Status
License
File Access
Controlled