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The CONNECT project: Combining macro- and micro-structure
Assaf, Yaniv Alexander, Daniel C. Jones, Derek Kenton Bizzi, Albero Behrens, Tim E. J. Clark, Chris A. Cohen, Yoram Dyrby, Tim B. Huppi, Petra S. Knoesche, Thomas R.
Assaf, Yaniv
Alexander, Daniel C.
Jones, Derek Kenton
Bizzi, Albero
Behrens, Tim E. J.
Clark, Chris A.
Cohen, Yoram
Dyrby, Tim B.
Huppi, Petra S.
Knoesche, Thomas R.
Author
Assaf, Yaniv
Alexander, Daniel C.
Jones, Derek Kenton
Bizzi, Albero
Behrens, Tim E. J.
Clark, Chris A.
Cohen, Yoram
Dyrby, Tim B.
Huppi, Petra S.
Knoesche, Thomas R.
LeBihan, Denis
Parker, Geoff J. M.
Poupon, Cyril
Anaby, Debbie
Anwander, Alfred
Bar, Leah
Barazany, Daniel
Blumenfeld-Katzir, Tamar
De Santis, Silvia
Duclap, Delphine
Figini, Matteo
Fischi, Elda
Guevara, Pamela
Hubbard, Penny
Hofstetter, Shir
Jbabdi, Saad
Kunz, Nicolas
Lazeyras, Francois
Lebois, Alice
Liptrot, Matthew G.
Lundell, Henrik
Mangin, Jean-Francois
Dominguez, David Moreno
Morozov, Darya
Schreiber, Jan
Seunarine, Kiran K.
Nava, Simone
Riffert, Till
Sasson, Efrat
Schmitt, Benoit
Shemesh, Noam
Sotiropoulos, Stam N.
Tavor, Ido
Zhang, Hui
Zhou, Feng-Lei
Alexander, Daniel C.
Jones, Derek Kenton
Bizzi, Albero
Behrens, Tim E. J.
Clark, Chris A.
Cohen, Yoram
Dyrby, Tim B.
Huppi, Petra S.
Knoesche, Thomas R.
LeBihan, Denis
Parker, Geoff J. M.
Poupon, Cyril
Anaby, Debbie
Anwander, Alfred
Bar, Leah
Barazany, Daniel
Blumenfeld-Katzir, Tamar
De Santis, Silvia
Duclap, Delphine
Figini, Matteo
Fischi, Elda
Guevara, Pamela
Hubbard, Penny
Hofstetter, Shir
Jbabdi, Saad
Kunz, Nicolas
Lazeyras, Francois
Lebois, Alice
Liptrot, Matthew G.
Lundell, Henrik
Mangin, Jean-Francois
Dominguez, David Moreno
Morozov, Darya
Schreiber, Jan
Seunarine, Kiran K.
Nava, Simone
Riffert, Till
Sasson, Efrat
Schmitt, Benoit
Shemesh, Noam
Sotiropoulos, Stam N.
Tavor, Ido
Zhang, Hui
Zhou, Feng-Lei
Abstract
In recent years, diffusion MRI has become an extremely important tool for studying the morphology of living brain tissue, as it provides unique insights into both its macrostructure and microstructure. Recent applications of diffusion MRI aimed to characterize the structural connectome using tractography to infer connectivity between brain regions. In parallel to the development of tractography, additional diffusion MRI based frameworks (CHARMED, AxCaliber, ActiveAx) were developed enabling the extraction of a multitude of micro-structural parameters (axon diameter distribution, mean axonal diameter and axonal density). This unique insight into both tissue microstructure and connectivity has enormous potential value in understanding the structure and organization of the brain as well as providing unique insights to abnormalities that underpin disease states. The CONNECT (Consortium Of Neuroimagers for the Non-invasive Exploration of brain Connectivity and Tracts) project aimed to combine tractography and micro-structural measures of the living human brain in order to obtain a better estimate of the connectome, while also striving to extend validation of these measurements. This paper summarizes the project and describes the perspective of using micro-structural measures to study the connectome.
Keywords
Date
2013
Type
Journal article
Journal
NeuroImage
Book
Volume
80
Issue
Page Range
273-282
Article Number
ACU Department
Relation URI
Source URL
Event URL
Open Access Status
License
File Access
Controlled