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Do comorbid personality disorders in cocaine dependence exacerbate neuroanatomical alterations? A structural neuroimaging study
Roberts, Carl A. Lorenzetti, Valentina Albein-Urios, Natalia Kowalczyk, Magdalena A. Martinez-Gonzalez, Jose M. Verdejo-Garcia, Antonio
Roberts, Carl A.
Lorenzetti, Valentina
Albein-Urios, Natalia
Kowalczyk, Magdalena A.
Martinez-Gonzalez, Jose M.
Verdejo-Garcia, Antonio
Abstract
Cocaine dependence (CD) is highly comorbid with personality disorders, with implications for poorer treatment response. The neurobiological mechanisms of this comorbidity are unclear. We aimed to test the role of comorbid personality disorders in the neuroanatomy of CD. We examined 4 groups using high-resolution structural neuroimaging, psychological questionnaires and cognitive tests: CD (n = 19), CD and personality disorder type B (CD + B, n = 21), CD and personality disorder C (CD + C, n = 13) and 21 controls. We compared groups in neuroanatomy and hypothesised that (i) CD would show altered striatal areas ascribed to reward processing (i.e., accumbens, caudate and putamen), (ii) CD + B and CD + C would show altered areas supporting emotional regulation/social valuation and anxiety/avoidance (i.e., OFC and amygdala). The CD + B group had larger caudate volumes than CD (p = .01, d = 0.94) and reduced lateral OFC thickness than CD + C (p = .056, d = 0.71). Exploratory correlations showed that altered neural integrity of the OFC and of the caudate nucleus in these groups exacerbated with worse personality disorder severity and impulsivity scores. CD with and without comorbid personality disorders may have partially distinct underlying mechanisms and targets for treatment.
Keywords
addiction, cocaine dependence, dual diagnosis, neuroanatomy, personality disorders
Date
2021
Type
Journal article
Journal
Progress in Neuropsychopharmacology and Biological Psychiatry
Book
Volume
110
Issue
Page Range
1-7
Article Number
Article 110298
ACU Department
School of Behavioural and Health Sciences
Faculty of Health Sciences
Faculty of Health Sciences
Relation URI
Source URL
Event URL
Open Access Status
License
All rights reserved
File Access
Controlled