Loading...
Trials with patient-reported outcomes registered on the Australian New Zealand clinical trials registry (ANZCTR)
Mercieca-Bebber, Rebecca Williams, Douglas Tait, Margaret-Ann Roydhouse, Jessica Busija, Lucy Sundaram, Chindhu S. Wilson, Michelle Langford, Ailsa Rutherford, Claudia Roberts, Natasha
Mercieca-Bebber, Rebecca
Williams, Douglas
Tait, Margaret-Ann
Roydhouse, Jessica
Busija, Lucy
Sundaram, Chindhu S.
Wilson, Michelle
Langford, Ailsa
Rutherford, Claudia
Roberts, Natasha
Abstract
Aims: It is important to understand the number, types and regions of trials that include patient-reported outcomes (PROs) to appreciate how patient experiences have been considered in studies of health and interventions. Twenty-seven percent of trials registered with ClinicalTrials.gov (2007–2013) included PROs; however, a regional breakdown was not provided and no reviews have been conducted of the Australia New Zealand Clinical Trials Registry (ANZCTR). We aimed to identify trials registered with ANZCTR with PRO endpoints and describe their characteristics. Methods: ANZCTR was systematically searched from inception (2005) to 31 March 2017 for trials with PRO endpoints. Search terms included PRO measures listed in Patient-Reported Outcomes Quality of Life Instrument Database and Grid-Enabled Measures, as well as generic PRO terms (e.g. “quality of life” (QOL)). Trial endpoints were individually coded using an established framework to identify trials with PROs for the analysis. Results: Of 13,666 registered trials, 6168 (45.1%) included a PRO. The proportion of studies including PROs increased between 2006 and 2016 (r = 0.74, p = 0.009). Among the 6168 trials, there were 17,961 individual PRO endpoints, including symptoms/functional outcomes/condition-specific QOL (65.6%), generic QOL (13.2%), patient-reported experiences (9.9%), patient-reported behaviours (7.9%). Mental health was the most common category (99.8% included PROs), followed by physical medicine/rehabilitation (65.6%), musculoskeletal (63.5%), public health (63.1%), and cancer (54.2%). Discussion: Our findings suggest growing use of PROs in the assessment of health and interventions in ANZ. Our review identifies trial categories with limited patient-reported information and provides a basis for future work on the impact of PRO findings in clinical care.
Keywords
Date
2018
Type
Journal article
Journal
Quality of Life Research
Book
Volume
27
Issue
10
Page Range
2581-2591
Article Number
ACU Department
Collections
Relation URI
Source URL
Event URL
Open Access Status
License
File Access
Controlled