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Global, regional, and national burden of Parkinson's disease, 1990–2016: A systematic analysis for the Global Burden of Disease Study 2016
Dorsey, E. Ray Elbaz, Alexis Nichols, Emma Abd-Allah, Foad Abdelalim, Ahmed Adsuar, Jose C. Ansha, Mustafa Geleto Brayne, Carol Choi, Jee-Young J. Collado-Mateo, Daniel
Dorsey, E. Ray
Elbaz, Alexis
Nichols, Emma
Abd-Allah, Foad
Abdelalim, Ahmed
Adsuar, Jose C.
Ansha, Mustafa Geleto
Brayne, Carol
Choi, Jee-Young J.
Collado-Mateo, Daniel
Author
Dorsey, E. Ray
Elbaz, Alexis
Nichols, Emma
Abd-Allah, Foad
Abdelalim, Ahmed
Adsuar, Jose C.
Ansha, Mustafa Geleto
Brayne, Carol
Choi, Jee-Young J.
Collado-Mateo, Daniel
Dahodwala, Nabila
Do, Huyen Phuc
Edessa, Dumessa
Endres, Matthias
Fereshtehnejad, Seyed-Mohammad
Foreman, Kyle J.
Gankpe, Fortune Gbetoho
Gupta, Rahul
Hankey, Graeme J.
Hay, Simon I.
Hegazy, Mohamed I.
Hibstu, Desalegn T.
Kasaeian, Amir
Khader, Yousef Saleh
Khalil, Ibrahim
Khang, Young-Ho
Kim, Yun Jin
Kokubo, Yoshihiro
Logroscino, Giancarlo
Massano, João
Mohamed Ibrahim, Norlinah
Mohammed, A. Mohammed
Mohammadi, Alireza
Moradi-Lakeh, Maziar
Naghavi, Mohsen
Nguyen, Binh Thanh
Nirayo, Yirga Legesse
Ogbo, Felix Akpojene
Owolabi, Mayowa Ojo
Pereira, David M.
Postma, Maarten J.
Qorbani, Mostafa
Rahman, Muhammad Aziz
Roba, Kedir T.
Safari, Hosein
Safiri, Saeid
Satpathy, Maheswar
Sawhney, Monika
Shafieesabet, Azadeh
Shiferaw, Mekonnen Sisay
Smith, Mari
Szoeke, Cassandra E. I.
Tabarés-Seisdedos, Rafael
Truong, Nu Thi
Ukwaja, Kingsley Nnanna
Venketasubramanian, Narayanaswamy
Villafaina, Santos
Weldegwergs, Kidu Gidey
Westerman, Ronny
Wijeratne, Tissa
Winkler, Andrea S.
Xuan, Bach Tran
Yonemoto, Naohiro
Feigin, Valery L.
Vos, Theo
Murray, Christopher J. L.
Elbaz, Alexis
Nichols, Emma
Abd-Allah, Foad
Abdelalim, Ahmed
Adsuar, Jose C.
Ansha, Mustafa Geleto
Brayne, Carol
Choi, Jee-Young J.
Collado-Mateo, Daniel
Dahodwala, Nabila
Do, Huyen Phuc
Edessa, Dumessa
Endres, Matthias
Fereshtehnejad, Seyed-Mohammad
Foreman, Kyle J.
Gankpe, Fortune Gbetoho
Gupta, Rahul
Hankey, Graeme J.
Hay, Simon I.
Hegazy, Mohamed I.
Hibstu, Desalegn T.
Kasaeian, Amir
Khader, Yousef Saleh
Khalil, Ibrahim
Khang, Young-Ho
Kim, Yun Jin
Kokubo, Yoshihiro
Logroscino, Giancarlo
Massano, João
Mohamed Ibrahim, Norlinah
Mohammed, A. Mohammed
Mohammadi, Alireza
Moradi-Lakeh, Maziar
Naghavi, Mohsen
Nguyen, Binh Thanh
Nirayo, Yirga Legesse
Ogbo, Felix Akpojene
Owolabi, Mayowa Ojo
Pereira, David M.
Postma, Maarten J.
Qorbani, Mostafa
Rahman, Muhammad Aziz
Roba, Kedir T.
Safari, Hosein
Safiri, Saeid
Satpathy, Maheswar
Sawhney, Monika
Shafieesabet, Azadeh
Shiferaw, Mekonnen Sisay
Smith, Mari
Szoeke, Cassandra E. I.
Tabarés-Seisdedos, Rafael
Truong, Nu Thi
Ukwaja, Kingsley Nnanna
Venketasubramanian, Narayanaswamy
Villafaina, Santos
Weldegwergs, Kidu Gidey
Westerman, Ronny
Wijeratne, Tissa
Winkler, Andrea S.
Xuan, Bach Tran
Yonemoto, Naohiro
Feigin, Valery L.
Vos, Theo
Murray, Christopher J. L.
Abstract
Background Neurological disorders are now the leading source of disability globally, and ageing is increasing the burden of neurodegenerative disorders, including Parkinson's disease. We aimed to determine the global burden of Parkinson's disease between 1990 and 2016 to identify trends and to enable appropriate public health, medical, and scientific responses. Methods Through a systematic analysis of epidemiological studies, we estimated global, regional, and country-specific prevalence and years of life lived with disability for Parkinson's disease from 1990 to 2016. We estimated the proportion of mild, moderate, and severe Parkinson's disease on the basis of studies that used the Hoehn and Yahr scale and assigned disability weights to each level. We jointly modelled prevalence and excess mortality risk in a natural history model to derive estimates of deaths due to Parkinson's disease. Death counts were multiplied by values from the Global Burden of Disease study's standard life expectancy to compute years of life lost. Disability-adjusted life-years (DALYs) were computed as the sum of years lived with disability and years of life lost. We also analysed results based on the Socio-demographic Index, a compound measure of income per capita, education, and fertility. Findings In 2016, 6·1 million (95% uncertainty interval [UI] 5·0–7·3) individuals had Parkinson's disease globally, compared with 2·5 million (2·0–3·0) in 1990. This increase was not solely due to increasing numbers of older people, because age-standardised prevalence rates increased by 21·7% (95% UI 18·1–25·3) over the same period (compared with an increase of 74·3%, 95% UI 69·2–79·6, for crude prevalence rates). Parkinson's disease caused 3·2 million (95% UI 2·6–4·0) DALYs and 211 296 deaths (95% UI 167 771–265 160) in 2016. The male-to-female ratios of age-standardised prevalence rates were similar in 2016 (1·40, 95% UI 1·36–1·43) and 1990 (1·37, 1·34–1·40). From 1990 to 2016, age-standardised prevalence, DALY rates, and death rates increased for all global burden of disease regions except for southern Latin America, eastern Europe, and Oceania. In addition, age-standardised DALY rates generally increased across the Socio-demographic Index. Interpretation Over the past generation, the global burden of Parkinson's disease has more than doubled as a result of increasing numbers of older people, with potential contributions from longer disease duration and environmental factors. Demographic and potentially other factors are poised to increase the future burden of Parkinson's disease substantially. Funding Bill & Melinda Gates Foundation.
Keywords
Date
2018
Type
Journal article
Journal
The Lancet Neurology
Book
Volume
17
Issue
11
Page Range
939-953
Article Number
ACU Department
Relation URI
Source URL
Event URL
Open Access Status
Open access
License
CC BY 4.0
File Access
Controlled