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Alteration to hippocampal shape in cannabis users with and without schizophrenia
Solowij, Nadia Walterfang, Mark Lubman, Dan I. Whittle, Sarah Lorenzetti, Valentina Styner, Martin Velakoulis, Dennis Pantelis, Christos Yucel, Murat
Solowij, Nadia
Walterfang, Mark
Lubman, Dan I.
Whittle, Sarah
Lorenzetti, Valentina
Styner, Martin
Velakoulis, Dennis
Pantelis, Christos
Yucel, Murat
Abstract
Abnormalities in hippocampal morphology are characteristic of schizophrenia and have also been reported in chronic cannabis users. There is a paucity of research investigating potential additive effects of cannabis use on brain pathology associated with schizophrenia. In this study, we performed hippocampal shape analysis in cannabis-using and non-using patients with schizophrenia, healthy cannabis users and healthy non-using controls. Hippocampal shape changes were observed in each group relative to controls, with the greatest degree of alterations (i.e., deflations across the hippocampus, and with an anterior predisposition), in cannabis-using schizophrenia patients. These alterations were associated with cannabis use patterns and psychotic symptoms.
Keywords
cannabis, schizophrenia, hippocampus, shape analysis, neuroimaging
Date
2013
Type
Journal article
Journal
Schizophrenia Research
Book
Volume
143
Issue
1
Page Range
179-184
Article Number
ACU Department
School of Behavioural and Health Sciences
Faculty of Health Sciences
Faculty of Health Sciences
Relation URI
Source URL
Event URL
Open Access Status
License
File Access
Controlled