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Bones material constituents and their contribution to bone strength in health, disease, and treatment
Bala, Y. Seeman, Ego
Bala, Y.
Seeman, Ego
Author
Abstract
Type 1 collagen matrix volume, its degree of completeness of its mineralization, the extent of collagen crosslinking and water content, and the non-collagenous proteins like osteopontin and osteocalcin comprise the main constituents of bone’s material composition. Each influences material strength and change in different ways during advancing age, health, disease, and drug therapy. These traits are not quantifiable using bone densitometry and their plurality is better captured by the term bone ‘qualities’ than ‘quality’. These qualities are the subject of this manuscript.
Keywords
bone water, collagen, mineralization, osteopontin, osteocalcin, pentosidine, qualities of bone
Date
2015
Type
Journal article
Journal
Calcified Tissue International
Book
Volume
97
Issue
3
Page Range
308-326
Article Number
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
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Relation URI
Source URL
Event URL
Open Access Status
License
File Access
Controlled