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SGC-CAMKK2-1 : A chemical probe for CAMKK2
Wells, Carrow Liang, Yi Pulliam, Thomas L. Lin, Chenchu Awad, Dominik Eduful, Benjamin O’Byrne, Sean Hossain, Mohammad Anwar Catta-Preta, Carolina Moura Costa Ramos, Priscila Zonzini
Wells, Carrow
Liang, Yi
Pulliam, Thomas L.
Lin, Chenchu
Awad, Dominik
Eduful, Benjamin
O’Byrne, Sean
Hossain, Mohammad Anwar
Catta-Preta, Carolina Moura Costa
Ramos, Priscila Zonzini
Author
Wells, Carrow
Liang, Yi
Pulliam, Thomas L.
Lin, Chenchu
Awad, Dominik
Eduful, Benjamin
O’Byrne, Sean
Hossain, Mohammad Anwar
Catta-Preta, Carolina Moura Costa
Ramos, Priscila Zonzini
Gileadi, Opher
Gileadi, Carina
Couñago, Rafael M.
Stork, Brittany
Langendorf, Christopher G.
Nay, Kevin
Oakhill, Jonathan S.
Mukherjee, Debarati
Racioppi, Luigi
Means, Anthony R.
York, Brian
McDonnell, Donald P.
Scott, John W.
Frigo, Daniel E.
Drewry, David H.
Liang, Yi
Pulliam, Thomas L.
Lin, Chenchu
Awad, Dominik
Eduful, Benjamin
O’Byrne, Sean
Hossain, Mohammad Anwar
Catta-Preta, Carolina Moura Costa
Ramos, Priscila Zonzini
Gileadi, Opher
Gileadi, Carina
Couñago, Rafael M.
Stork, Brittany
Langendorf, Christopher G.
Nay, Kevin
Oakhill, Jonathan S.
Mukherjee, Debarati
Racioppi, Luigi
Means, Anthony R.
York, Brian
McDonnell, Donald P.
Scott, John W.
Frigo, Daniel E.
Drewry, David H.
Abstract
The serine/threonine protein kinase calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) plays critical roles in a range of biological processes. Despite its importance, only a handful of inhibitors of CAMKK2 have been disclosed. Having a selective small molecule tool to interrogate this kinase will help demonstrate that CAMKK2 inhibition can be therapeutically beneficial. Herein, we disclose SGC-CAMKK2-1, a selective chemical probe that targets CAMKK2.
Keywords
CAMKK2, kinase, chemical probe, NanoBRET, kinase selectivity
Date
2023
Type
Journal article
Journal
Cells
Book
Volume
12
Issue
2
Page Range
1-17
Article Number
Article 287
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Non-faculty
Faculty of Health Sciences
Non-faculty
Collections
Relation URI
Source URL
Event URL
Open Access Status
Published as ‘gold’ (paid) open access
License
CC BY 4.0
File Access
Open