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A pocket guide on how to structure SARS-CoV-2 drugs and therapies
Littler, Dene R. MacLachlan, Bruce J. Watson, Gabrielle M. Vivian, Julian Philip Gully, Benjamin S.
Littler, Dene R.
MacLachlan, Bruce J.
Watson, Gabrielle M.
Vivian, Julian Philip
Gully, Benjamin S.
Abstract
The race to identify a successful treatment for COVID19 will be defined by fundamental research into the replication cycle of the SARS-CoV-2 virus. This has identified five distinct stages from which numerous vaccination and clinical trials have emerged alongside an innumerable number of drug discovery studies currently in development for disease intervention. Informing every step of the viral replication cycle has been an unprecedented ‘call-to-arms' by the global structural biology community. Of the 20 main SARS-CoV-2 proteins, 13 have been resolved structurally for SARS-CoV-2 with most having a related SARS-CoV and MERS-CoV structural homologue totalling some 300 structures currently available in public repositories. Herein, we review the contribution of structural studies to our understanding of the virus and their role in structure-based development of therapeutics.
Keywords
COVID-19, SARS-CoV-2, structural biology
Date
2020
Type
Journal article
Journal
Biochemical Society Transactions
Book
Volume
48
Issue
6
Page Range
2625-2641
Article Number
ACU Department
Marketing and Communications
Research Office
Research Office
Collections
Files
Relation URI
Event URL
Open Access Status
Published as ‘gold’ (paid) open access
License
CC BY-NC-ND 4.0
File Access
Open
Notes
© 2020 The Author(s).
This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NCND). https://creativecommons.org/licenses/by-nc-nd/4.0/
This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NCND). https://creativecommons.org/licenses/by-nc-nd/4.0/