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Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression
Leonidas S Lundell Evelyn Parr Brooke Devlin Lars R Ingerslev Ali Altintas Shogo Sato Paolo Sassone-Corsi Romain Barres Juleen R Zierath John Hawley
Leonidas S Lundell
Evelyn Parr
Brooke Devlin
Lars R Ingerslev
Ali Altintas
Shogo Sato
Paolo Sassone-Corsi
Romain Barres
Juleen R Zierath
John Hawley
Abstract
Time-restricted feeding (TRF) improves metabolism independent of dietary macronutrient composition or energy restriction. To elucidate mechanisms underpinning the effects of short-term TRF, we investigated skeletal muscle and serum metabolic and transcriptomic profiles from 11 men with overweight/obesity after TRF (8 h day−1) and extended feeding (EXF, 15 h day−1) in a randomised cross-over design (trial registration: ACTRN12617000165381). Here we show that muscle core clock gene expression was similar after both interventions. TRF increases the amplitude of oscillating muscle transcripts, but not muscle or serum metabolites. In muscle, TRF induces rhythmicity of several amino acid transporter genes and metabolites. In serum, lipids are the largest class of periodic metabolites, while the majority of phase-shifted metabolites are amino acid related. In conclusion, short-term TRF in overweight men affects the rhythmicity of serum and muscle metabolites and regulates the rhythmicity of genes controlling amino acid transport, without perturbing core clock gene expression.
Keywords
Date
2020
Type
Journal article
Journal
Nature Communications
Book
Volume
11
Issue
1
Page Range
1-11
Article Number
ACU Department
Centre for Exercise and Nutrition
Faculty of Health Sciences
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Mary MacKillop Institute for Health Research
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Relation URI
Source URL
Event URL
Open Access Status
Published as ‘gold’ (paid) open access
License
CC BY 4.0
File Access
Open