Loading...
Large meta-analysis of genome-wide association studies identifies five loci for lean body mass
Zillikens, M. Carola Demissie, Serkalem Hsu, Yi-Hsiang Yerges-Armstrong, Laura M. Chou, Wen-Chi Stolk, Lisette Livshits, Gregory Broer, Linda Johnson, Toby Koller, Daniel L.
Zillikens, M. Carola
Demissie, Serkalem
Hsu, Yi-Hsiang
Yerges-Armstrong, Laura M.
Chou, Wen-Chi
Stolk, Lisette
Livshits, Gregory
Broer, Linda
Johnson, Toby
Koller, Daniel L.
Author
Zillikens, M. Carola
Demissie, Serkalem
Hsu, Yi-Hsiang
Yerges-Armstrong, Laura M.
Chou, Wen-Chi
Stolk, Lisette
Livshits, Gregory
Broer, Linda
Johnson, Toby
Koller, Daniel L.
Kutalik, Zoltán
Luan, Jian'an
Malkin, Ida
Ried, Janina S.
Smith, Albert V.
Thorleifsson, Gudmar
Vandenput, Liesbeth
Zhao, Jing Hua
Zhang, Weihua
Aghdassi, Ali
Åkesson, Kristina
Amin, Najaf
Baier, Leslie J.
Barroso, Inês
Bennett, David A.
Bertram, Lars
Biffar, Rainer
Bochud, Murielle
Boehnke, Michael
Demissie, Serkalem
Hsu, Yi-Hsiang
Yerges-Armstrong, Laura M.
Chou, Wen-Chi
Stolk, Lisette
Livshits, Gregory
Broer, Linda
Johnson, Toby
Koller, Daniel L.
Kutalik, Zoltán
Luan, Jian'an
Malkin, Ida
Ried, Janina S.
Smith, Albert V.
Thorleifsson, Gudmar
Vandenput, Liesbeth
Zhao, Jing Hua
Zhang, Weihua
Aghdassi, Ali
Åkesson, Kristina
Amin, Najaf
Baier, Leslie J.
Barroso, Inês
Bennett, David A.
Bertram, Lars
Biffar, Rainer
Bochud, Murielle
Boehnke, Michael
Abstract
Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass (n = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one single-nucleotide polymorphisms were significantly associated with lean body mass either genome wide (p < 5 × 10−8) or suggestively genome wide (p < 2.3 × 10−6). Replication in 63,475 (47,227 of European ancestry) individuals from 33 cohorts for whole body lean body mass and in 45,090 (42,360 of European ancestry) subjects from 25 cohorts for appendicular lean body mass was successful for five single-nucleotide polymorphisms in/near HSD17B11, VCAN, ADAMTSL3, IRS1, and FTO for total lean body mass and for three single-nucleotide polymorphisms in/near VCAN, ADAMTSL3, and IRS1 for appendicular lean body mass. Our findings provide new insight into the genetics of lean body mass.
Keywords
Date
2017
Type
Journal article
Journal
Nature Communications
Book
Volume
8
Issue
1
Page Range
1-13
Article Number
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
Open access
License
CC BY 4.0
File Access
Controlled
Notes
Please refer to the full article for a complete list of author names.