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Association of the microRNA-Single Nucleotide Polymorphism rs2910164 in miR146a with sporadic breast cancer susceptibility : A case control study
Upadhyaya, Akanksha Smith, Robert A. Chacon-Cortes, Diego Revêchon, Gwladys Bellis, Claire Lea, Rod A. Haupt, Larisa M. Chambers, Suzanne K. Youl, Philippa H. Griffiths, Lyn R.
Upadhyaya, Akanksha
Smith, Robert A.
Chacon-Cortes, Diego
Revêchon, Gwladys
Bellis, Claire
Lea, Rod A.
Haupt, Larisa M.
Chambers, Suzanne K.
Youl, Philippa H.
Griffiths, Lyn R.
Abstract
Background
Breast cancer (BC) is primarily considered a genetic disorder with a complex interplay of factors including age, gender, ethnicity, family history, personal history and lifestyle with associated hormonal and non-hormonal risk factors. The SNP rs2910164 in miR146a (a G to C polymorphism) was previously associated with increased risk of BC in cases with at least a single copy of the C allele in breast cancer, though results in other cancers and populations have shown significant variation.
Methods
In this study, we examined this SNP in an Australian sporadic breast cancer population of 160 cases and matched controls, with a replicate population of 403 breast cancer cases using High Resolution Melting.
Results
Our analysis indicated that the rs2910164 polymorphism is associated with breast cancer risk in both primary and replicate populations (p = 0.03 and 0.0013, respectively). In contrast to the results of familial breast cancer studies, however, we found that the presence of the G allele of rs2910164 is associated with increased cancer risk, with an OR of 1.77 (95% CI 1.40–2.23).
Conclusions
The microRNA miR146a has a potential role in the development of breast cancer and the effects of its SNPs require further inquiry to determine the nature of their influence on breast tissue and cancer.
Keywords
miR146a, polymorphism, breast cancer, BRCA, SNP, miRNA
Date
2016
Type
Journal article
Journal
Gene
Book
Volume
576
Issue
1
Page Range
256-260
Article Number
ACU Department
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
License
All rights reserved
File Access
Controlled