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Oxytocin and vasopressin in the human brain: Social neuropeptides for translational medicine
Meyer-Lindenberg, Andreas Domes, Gregor Kirsch, Peter Heinrichs, Markus
Meyer-Lindenberg, Andreas
Domes, Gregor
Kirsch, Peter
Heinrichs, Markus
Abstract
The neuropeptides oxytocin ( OXT ) and arginine vasopressin ( AVP ) are evolutionarily highly conserved mediators in the regulation of complex social cognition and behaviour. Recent studies have investigated the effects of OXT and AVP on human social interaction, the genetic mechanisms of inter-individual variation in social neuropeptide signalling and the actions of OXT and AVP in the human brain as revealed by neuroimaging. These data have advanced our understanding of the mechanisms by which these neuropeptides contribute to human social behaviour. OXT and AVP are emerging as targets for novel treatment approaches — particularly in synergistic combination with psychotherapy — for mental disorders characterized by social dysfunction, such as autism, social anxiety disorder, borderline personality disorder and schizophrenia.
Keywords
Date
2011
Type
Journal article
Journal
Nature Reviews Neuroscience
Book
Volume
12
Issue
9
Page Range
524-538
Article Number
ACU Department
School of Behavioural and Health Sciences
Faculty of Health Sciences
Faculty of Health Sciences
Relation URI
DOI
Source URL
Event URL
Open Access Status
License
File Access
Controlled