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Exploring the brain-body composition relationship in Huntington's disease
Mitchell Turner Alvaro Reyes Danielle M. Bartlett Scott Culpin Nicolas H. Hart Luca Hardt Kirk Feindel Govinda R. Poudel Mel Ziman Travis M. Cruickshank
Mitchell Turner
Alvaro Reyes
Danielle M. Bartlett
Scott Culpin
Nicolas H. Hart
Luca Hardt
Kirk Feindel
Govinda R. Poudel
Mel Ziman
Travis M. Cruickshank
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Abstract
Objective: Changes in body composition are a common feature of Huntington’s disease (HD) and are associated with disease progression. However, whether these changes in body composition are associated with degeneration of the striatum is unknown. This study aimed to explore the associations between body composition metrics and striatal brain volume in individuals with premanifest HD and healthy controls. Methods: Twenty-one individuals with premanifest HD and 22 healthy controls participated in this cross-sectional study. Body composition metrics were measured via dualenergy X-ray absorptiometry. Structural magnetic resonance imaging of subcortical structures of the brain was performed to evaluate striatal volume. Results: There were no significant differences in body composition metrics between the premanifest HD and healthy controls group. Striatal volume was significantly reduced in individuals with premanifest HD compared to healthy controls. A significant association between bone mineral density (BMD) and right putamen volume was also observed in individuals with premanifest HD. Conclusion: These findings show striatal degeneration is evident during the premanifest stages of HD and associated with BMD. Additional longitudinal studies are nevertheless needed to confirm these findings.
Keywords
bone mineral density, caudate volume, fat percentage, putamen volume, striatum volume
Date
2020
Type
Journal article
Journal
The Journal of Musculoskeletal and Neuronal Interactions
Book
Volume
20
Issue
3
Page Range
332-338
Article Number
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
Collections
Relation URI
DOI
Source URL
Event URL
Open Access Status
Open access
License
CC BY-NC-SA 4.0
File Access
Open