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High-intensity interval training in polycystic ovary syndrome : A two-center, three-armed randomized
Kiel, Ida A. Lionett, Sofie Parr, Evelyn B. Jones, Helen Røset, Maria A. H. Salvesen, Øyvind Hawley, John A. Vanky, Eszter Moholdt, Trine
Kiel, Ida A.
Lionett, Sofie
Parr, Evelyn B.
Jones, Helen
Røset, Maria A. H.
Salvesen, Øyvind
Hawley, John A.
Vanky, Eszter
Moholdt, Trine
Abstract
Purpose
Exercise training is recommended to improve cardiometabolic health and fertility in women with polycystic ovary syndrome (PCOS), yet there are few randomized controlled trials on the effects of different exercise protocols on clinical reproductive outcomes. Our aim was to determine the effect of high-intensity interval training (HIT) on menstrual frequency, as a proxy of reproductive function, in women with PCOS.
Methods
The IMPROV-IT study was a two-center randomized controlled trial undertaken in Norway and Australia. Women with PCOS were eligible for inclusion. After stratification for body mass index <27 or ≥27 kg·m−2 and study center, participants were randomly allocated (1:1:1) to high-volume HIT (HV-HIT), low-volume HIT (LV-HIT), or a control group. Measurements were assessed at baseline, after the 16-wk exercise intervention, and at 12-month follow-up. The primary outcome was menstrual frequency after 12 months. Secondary outcomes included markers of cardiometabolic and reproductive health, quality of life, and adherence to and enjoyment of HIT.
Results
We randomly allocated 64 participants to the HV-HIT (n = 20), LV-HIT (n = 21), or control group (n = 23). There were no differences in menstrual frequency at 12 months between the LV-HIT and control groups (frequency ratio, 1.02; 95% confidence interval [CI], 0.73–1.42), the HV-HIT and control groups (frequency ratio, 0.93; 95% CI, 0.67–1.29), or the LV-HIT and HV-HIT groups (frequency ratio, 1.09; 95% CI, 0.77–1.56). Menstrual frequency increased in all groups from baseline to 12 months. More participants became pregnant in the LV-HIT group (n = 5) than in the control group (n = 0, P = 0.02).
Conclusions
A semisupervised HIT intervention did not increase menstrual frequency in women with PCOS.
Clinical Trial Registration Number:ClinicalTrials.gov (NCT02419482).
Keywords
exercise training, PCOS, menstrual frequency, reproductive health
Date
2022
Type
Journal article
Journal
Medicine and Science in Sports and Exercise
Book
Volume
54
Issue
5
Page Range
717-727
Article Number
ACU Department
Centre for Exercise and Nutrition
Faculty of Health Sciences
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Mary MacKillop Institute for Health Research
Collections
Relation URI
Source URL
Event URL
Open Access Status
Published as green open access
License
File Access
Open
Controlled
Controlled