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Potential roles of n-3 PUFAs during skeletal muscle growth and regeneration
Tachtsis, Bill Camera, Donny Lacham-Kaplan, Orly
Tachtsis, Bill
Camera, Donny
Lacham-Kaplan, Orly
Abstract
Omega-3 polyunsaturated fatty acids (n-3 PUFAs), which are commonly found in fish oil supplements, are known to possess anti-inflammatory properties and more recently alter skeletal musclefunction. In this review, we discuss novel findings related to how n-3 PUFAs modulate molecular signaling responsible for growth and hypertrophy as well as the activity of muscle stem cells. Muscle stem cells commonly known as satellite cells, are primarily responsible for driving the skeletal muscle repair process to potentially damaging stimuli, such as mechanical stress elicited by exercise contraction. To date, there is a paucity of human investigations related to the effects of n-3 PUFAs on satellite cell content and activity. Based on current in vitro investigations, this review focuses on novel mechanisms linking n-3 PUFA’s to satellite cell activity and how they may improve muscle repair. Understanding the role of n-3 PUFAs during muscle growth and regeneration in association with exercise could lead to the development of novel supplementation strategies that increase muscle mass and strength, therefore possibly reducing the burden of muscle wasting with age.
Keywords
ageing, Omega-3, satellite cells, skeletal muscle
Date
2018
Type
Journal article
Journal
Nutrients
Book
Volume
10
Issue
3
Page Range
1-20
Article Number
ACU Department
School of Behavioural and Health Sciences
Faculty of Health Sciences
Non-faculty
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Non-faculty
Mary MacKillop Institute for Health Research
Relation URI
Source URL
Event URL
Open Access Status
License
File Access
Controlled