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Long-term exposure to elemental constituents of particulate matter and cardiovascular mortality in 19 European cohorts: Results from the ESCAPE and TRANSPHORM projects
Wang, Meng Beelen, Rob Stafoggia, M. Raaschou-Nielsen, Ole Andersen, Zorana Jovanovic Hoffmann, Barbara Fischer, P. Houthuijs, Danny Nieuwenhuijsen, Mark Weinmayr, Gudrun
Wang, Meng
Beelen, Rob
Stafoggia, M.
Raaschou-Nielsen, Ole
Andersen, Zorana Jovanovic
Hoffmann, Barbara
Fischer, P.
Houthuijs, Danny
Nieuwenhuijsen, Mark
Weinmayr, Gudrun
Author
Wang, Meng
Beelen, Rob
Stafoggia, M.
Raaschou-Nielsen, Ole
Andersen, Zorana Jovanovic
Hoffmann, Barbara
Fischer, P.
Houthuijs, Danny
Nieuwenhuijsen, Mark
Weinmayr, Gudrun
Vineis, Paolo
Xun, W.W.
Dimakopoulou, Konstantina
Samoli, E.
Laatikainen, T.
Lanki, Timo
Turunen, Anu W.
Oftedal, Bente
Schwarze, P. E.
Aamodt, Geir
Penell, Johanna
De Faire, Ulf
Korek, Michal
Leander, Karin
Pershagen, Göran
Pedersen, N.
Östenson, Claes-Göran
Fratiglioni, Laura
Eriksen, Kirsten Thorup
Sørensen, Mette
Tjønneland, Anne
Bueno-de-Mesquita, Bas
Eeftensa, Marloes
Bots, Michiel L.
Meliefste, Kees
Krämer, Ursula
Heinrich, Joachim
Sugiri, Dorothea
Key, Timothy
de Hoogh, Kees
Wolf, Kathrin
Peters, Annette
Cyrys, Josef
Jaensch, Andrea
Concin, Hans
Nagel, Gabriele
Tsai, Ming-Yi
Phuleria, Harish
Ineichen, Alex
Künzli, Nino
Probst-Hensch, Nicole
Schaffner, Emmanuel
Vilier, Alice
Clavel-Chapelon, Françoise
Declerq, Christophe
Ricceri, Fulvio
Sacerdote, Carlotta
Marcon, Alessandro
Galassi, Claudia
Migliore, Enrica
Ranzi, Andrea
Cesaroni, Giulia
Badaloni, Chiara
Forastiere, Francesco
Katsoulis, Michail
Trichopoulou, Antonia
Keuken, Menno
Jedynska, Aleksandra
Kooter, Ingeborg M.
Kukkonen, Jaakko
Sokhi, Ranjeet S.
Brunekreef, Bert
Katsouyanni, Klea
Hoeka, Gerard
Beelen, Rob
Stafoggia, M.
Raaschou-Nielsen, Ole
Andersen, Zorana Jovanovic
Hoffmann, Barbara
Fischer, P.
Houthuijs, Danny
Nieuwenhuijsen, Mark
Weinmayr, Gudrun
Vineis, Paolo
Xun, W.W.
Dimakopoulou, Konstantina
Samoli, E.
Laatikainen, T.
Lanki, Timo
Turunen, Anu W.
Oftedal, Bente
Schwarze, P. E.
Aamodt, Geir
Penell, Johanna
De Faire, Ulf
Korek, Michal
Leander, Karin
Pershagen, Göran
Pedersen, N.
Östenson, Claes-Göran
Fratiglioni, Laura
Eriksen, Kirsten Thorup
Sørensen, Mette
Tjønneland, Anne
Bueno-de-Mesquita, Bas
Eeftensa, Marloes
Bots, Michiel L.
Meliefste, Kees
Krämer, Ursula
Heinrich, Joachim
Sugiri, Dorothea
Key, Timothy
de Hoogh, Kees
Wolf, Kathrin
Peters, Annette
Cyrys, Josef
Jaensch, Andrea
Concin, Hans
Nagel, Gabriele
Tsai, Ming-Yi
Phuleria, Harish
Ineichen, Alex
Künzli, Nino
Probst-Hensch, Nicole
Schaffner, Emmanuel
Vilier, Alice
Clavel-Chapelon, Françoise
Declerq, Christophe
Ricceri, Fulvio
Sacerdote, Carlotta
Marcon, Alessandro
Galassi, Claudia
Migliore, Enrica
Ranzi, Andrea
Cesaroni, Giulia
Badaloni, Chiara
Forastiere, Francesco
Katsoulis, Michail
Trichopoulou, Antonia
Keuken, Menno
Jedynska, Aleksandra
Kooter, Ingeborg M.
Kukkonen, Jaakko
Sokhi, Ranjeet S.
Brunekreef, Bert
Katsouyanni, Klea
Hoeka, Gerard
Abstract
Background: Associations between long-term exposure to ambient particulate matter (PM) and cardiovascular (CVD) mortality have been widely recognized. However, health effects of long-term exposure to constituents of PM on total CVD mortality have been explored in a single study only. Aims: The aim of this study was to examine the association of PM composition with cardiovascular mortality. Methods: We used data from 19 European ongoing cohorts within the framework of the ESCAPE (European Study of Cohorts for Air Pollution Effects) and TRANSPHORM (Transport related Air Pollution and Health impacts — Integrated Methodologies for Assessing Particulate Matter) projects. Residential annual average exposure to elemental constituents within particle matter smaller than 2.5 and 10 μm (PM2.5 and PM10) was estimated using Land Use Regression models. Eight elements representing major sources were selected a priori (copper, iron, potassium, nickel, sulfur, silicon, vanadium and zinc). Cohort-specific analyses were conducted using Cox proportional hazards models with a standardized protocol. Random-effects meta-analysis was used to calculate combined effect estimates. Results: The total population consisted of 322,291 participants, with 9545 CVD deaths. We found no statistically significant associations between any of the elemental constituents in PM2.5 or PM10 and CVD mortality in the pooled analysis. Most of the hazard ratios (HRs) were close to unity, e.g. for PM10 Fe the combined HR was 0.96 (0.84–1.09). Elevated combined HRs were found for PM2.5 Si (1.17, 95% CI: 0.93–1.47), and S in PM2.5 (1.08, 95% CI: 0.95–1.22) and PM10 (1.09, 95% CI: 0.90–1.32). Conclusion: In a joint analysis of 19 European cohorts, we found no statistically significant association between long-term exposure to 8 elemental constituents of particles and total cardiovascular mortality.
Keywords
long-term exposure, particulate matter, constituents, cardiovascular mortality, ESCAPE, TRANSPHORM
Date
2014
Type
Journal article
Journal
Environment International
Book
Volume
66
Issue
Page Range
97-106
Article Number
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
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Relation URI
Source URL
Event URL
Open Access Status
License
File Access
Controlled