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Natural product-derived phytochemicals as potential agents against coronaviruses : A review
Mani, Janice S. Johnson, Joel B. Steel, Jason C. Broszczak, Daniel A. Neilsen, Paul M. Walsh, Kerry B. Naiker, Mani
Mani, Janice S.
Johnson, Joel B.
Steel, Jason C.
Broszczak, Daniel A.
Neilsen, Paul M.
Walsh, Kerry B.
Naiker, Mani
Abstract
Coronaviruses are responsible for a growing economic, social and mortality burden, as the causative agent of diseases such as severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), avian infectious bronchitis virus (IBV) and COVID-19. However, there is a lack of effective antiviral agents for many coronavirus strains. Naturally existing compounds provide a wealth of chemical diversity, including antiviral activity, and thus may have utility as therapeutic agents against coronaviral infections. The PubMed database was searched for papers including the keywords coronavirus, SARS or MERS, as well as traditional medicine, herbal, remedy or plants, with 55 primary research articles identified. The overwhelming majority of publications focussed on polar compounds. Compounds that show promise for the inhibition of coronavirus in humans include scutellarein, silvestrol, tryptanthrin, saikosaponin B2, quercetin, myricetin, caffeic acid, psoralidin, isobavachalcone, and lectins such as griffithsin. Other compounds such as lycorine may be suitable if a therapeutic level of antiviral activity can be achieved without exceeding toxic plasma concentrations. It was noted that the most promising small molecules identified as coronavirus inhibitors contained a conjugated fused ring structure with the majority being classified as being polyphenols.
Keywords
Coronaviridae, Severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), traditional medicine, COVID-19, SARS-CoV-2
Date
2020
Type
Journal article
Journal
Virus Research
Book
Volume
284
Issue
Page Range
1-16
Article Number
Article 197989
ACU Department
Collections
Relation URI
Source URL
Event URL
Open Access Status
License
All rights reserved
File Access
Controlled