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Evidence-based guideline for the management of osteoporosis in men

Fuggle, Nicholas R.
Beaudart, Charlotte
Bruyère, Olivier
Abrahamsen, Bo
Al-Daghri, Nasser
Burlet, Nansa
Chandran, Manju
Rosa, Mario M.
Cortet, Bernard
Demonceau, Céline
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Abstract
Historically, osteoporosis has been viewed as a disease of women, with research, trials of interventions and guidelines predominantly focused as such. It is apparent, however, that this condition causes a substantial health burden in men also, and that its assessment and management must ultimately be addressed across both sexes. In this article, an international multidisciplinary working group of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases presents GRADE-assessed recommendations for the diagnosis, monitoring and treatment of osteoporosis in men. The recommendations are based on a comprehensive review of the latest research related to diagnostic and screening approaches for osteoporosis and its associated high fracture risk in men, covering disease burden, appropriate interpretation of bone densitometry (including the use of a female reference database for densitometric diagnosis in men) and absolute fracture risk, thresholds for treatment, and interventions that can be used therapeutically and their health economic evaluation. Future work should specifically address the efficacy of anti-osteoporosis medications, including denosumab and bone-forming therapies.
Keywords
Date
2024
Type
Journal article
Journal
Nature Reviews Rheumatology
Book
Volume
20
Issue
4
Page Range
241-251
Article Number
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
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Open Access Status
License
All rights reserved
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Controlled
Notes
© Springer Nature Limited 2024.