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Interpretation and use of FRAX in clinical practice
Kanis, John A. Hans, D. Cooper, Cyrus Baim, Sanford Bilezikian, J. P. Binkley, Neil Cauley, Jane A. Compston, Juliet E. Dawson-Hughes, Bess Fuleihan, Ghada El-Hajj
Kanis, John A.
Hans, D.
Cooper, Cyrus
Baim, Sanford
Bilezikian, J. P.
Binkley, Neil
Cauley, Jane A.
Compston, Juliet E.
Dawson-Hughes, Bess
Fuleihan, Ghada El-Hajj
Author
Kanis, John A.
Hans, D.
Cooper, Cyrus
Baim, Sanford
Bilezikian, J. P.
Binkley, Neil
Cauley, Jane A.
Compston, Juliet E.
Dawson-Hughes, Bess
Fuleihan, Ghada El-Hajj
Johansson, Helena
Leslie, William D.
Lewiecki, E. Michael
Luckey, Marjorie M.
Oden, Anders
Papapoulos, S.
Poiana, Catalina
Rizzoli, R
Wahl, D. A.
McCloskey, Eugene
Hans, D.
Cooper, Cyrus
Baim, Sanford
Bilezikian, J. P.
Binkley, Neil
Cauley, Jane A.
Compston, Juliet E.
Dawson-Hughes, Bess
Fuleihan, Ghada El-Hajj
Johansson, Helena
Leslie, William D.
Lewiecki, E. Michael
Luckey, Marjorie M.
Oden, Anders
Papapoulos, S.
Poiana, Catalina
Rizzoli, R
Wahl, D. A.
McCloskey, Eugene
Abstract
Summary The introduction of the WHO FRAX® algorithms has facilitated the assessment of fracture risk on the basis of fracture probability. Its use in fracture risk prediction has strengths, but also limitations of which the clinician should be aware and are the focus of this review Introduction The International Osteoporosis Foundation (IOF) and the International Society for Clinical Densitometry (ISCD) appointed a joint Task Force to develop resource documents in order to make recommendations on how to improve FRAX and better inform clinicians who use FRAX. The Task Force met in November 2010 for 3 days to discuss these topics which form the focus of this review. Methods This study reviews the resource documents and joint position statements of ISCD and IOF. Results Details on the clinical risk factors currently used in FRAX are provided, and the reasons for the exclusion of others are provided. Recommendations are made for the development of surrogate models where country-specific FRAX models are not available. Conclusions The wish list of clinicians for the modulation of FRAX is large, but in many instances, these wishes cannot presently be fulfilled; however, an explanation and understanding of the reasons may be helpful in translating the information provided by FRAX into clinical practice.
Keywords
Bone mineral density, Clinical risk factors, Fracture probability, Risk assessment
Date
2011
Type
Journal article
Journal
Osteoporosis International
Book
Volume
22
Issue
9
Page Range
2395-2411
Article Number
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
License
File Access
Controlled