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Significance of LL-37 on Immunomodulation and Disease Outcome
Binbin Yang David Good Tamim Mosaiab Wei Liu Guoying Ni Jasmine Kaur Xiaosong Liu Calvin Jessop Lu Yang Rushdi Fadhil
Binbin Yang
David Good
Tamim Mosaiab
Wei Liu
Guoying Ni
Jasmine Kaur
Xiaosong Liu
Calvin Jessop
Lu Yang
Rushdi Fadhil
Abstract
LL-37, also called cathelicidin, is an important part of the human immune system, which can resist various pathogens. A plethora of experiments have demonstrated that it has the multifunctional effects of immune regulation, in addition to antimicrobial activity. Recently, there have been increasing interest in its immune function. It was found that LL-37 can have two distinct functions in different tissues and different microenvironments. Thus, it is necessary to investigate LL-37 immune functions from the two sides of the same coin. On the one side, LL-37 promotes inflammation and immune response and exerts its anti-infective and antitumor effects; on the other side, it has the ability to inhibit inflammation and promote carcinogenesis. This review presents a brief summary of its expression, structure, and immunomodulatory effects as well as brief discussions on the role of this small peptide as a key factor in the development and treatment of various inflammation-related diseases and cancers.
Keywords
Date
2020
Type
Journal article
Journal
BioMed Research International
Book
Volume
2020
Issue
8349712
Page Range
1-16
Article Number
ACU Department
School of Allied Health
Faculty of Health Sciences
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
Published as ‘gold’ (paid) open access
License
File Access
Open