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Associations of sedentary time patterns and TV viewing time with inflammatory and endothelial function biomarkers in children
Gabel, Leigh Ridgers, Nicola D. Della Gatta, P. A. Arundell, Lauren Cerin, Ester Robinson, Sally Daly, Rob Dunstan, David Wayne Salmon, Jo
Gabel, Leigh
Ridgers, Nicola D.
Della Gatta, P. A.
Arundell, Lauren
Cerin, Ester
Robinson, Sally
Daly, Rob
Dunstan, David Wayne
Salmon, Jo
Abstract
Objective Investigate associations of TV viewing time and accelerometry-derived sedentary time with inflammatory and endothelial function biomarkers in children. Methods Cross-sectional analysis of 164 7–10-year-old children. TV viewing time was assessed by parental proxy report and total and patterns of sedentary time accumulation (e.g. prolonged bouts) were assessed by accelerometry. C-reactive protein (CRP), homeostasis model assessment of insulin resistance, interleukin-2, -6, -8, -10, tumour necrosis factor alpha, adiponectin, resistin, brain-derived neurotrophic factor, soluble intercellular and vascular adhesion molecule 1, plasminogen activator inhibitor 1 and soluble E-selectin were assessed. Generalised linear models assessed the associations of TV viewing and sedentary time with biomarkers, adjusting for sex, waist circumference, moderate- to vigorous-intensity physical activity and diet density. Results Each additional h week−1 of TV viewing was associated with 4.4% (95% CI: 2.1, 6.7) greater CRP and 0.6% (0.2, 1.0) greater sVCAM-1 in the fully adjusted model. The association between frequency and duration of 5–10 min bouts of sedentary time and CRP was positive after adjustment for sex and waist circumference but attenuated after adjustment for diet density. Conclusions This study suggests that TV viewing was unfavourably associated with several markers of inflammation and endothelial dysfunction. The detrimental association between 5 and 10 min bouts of sedentary time and CRP approached significance, suggesting that further research with a stronger study design (longitudinal and/or experimental) is needed to better understand how the accumulation of sedentary time early in life may influence short and longer term health.
Keywords
Date
2016
Type
Journal article
Journal
Pediatric Obesity
Book
Volume
11
Issue
3
Page Range
194-201
Article Number
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
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Relation URI
Source URL
Event URL
Open Access Status
License
File Access
Controlled