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Acute respiratory response to traffic-related air pollution during physical activity performance
Matt, Florian Cole-Hunter, Tom Donaire-Gonzalez, David Kubesch, Nadine Martínez, David Carrasco-Turigas, Glòria Nieuwenhuijsen, Mark
Matt, Florian
Cole-Hunter, Tom
Donaire-Gonzalez, David
Kubesch, Nadine
Martínez, David
Carrasco-Turigas, Glòria
Nieuwenhuijsen, Mark
Abstract
Background: Physical activity (PA) has beneficial, whereas exposure to traffic related air pollution (TRAP) has adverse, respiratory effects. Few studies, however, have examined if the acute effects of TRAP upon respiratory outcomes are modified depending on the level of PA. Objectives: The aim of our study was to disentangle acute effects of TRAP and PA upon respiratory outcomes and assess the impact of participants TRAP pre-exposure. Methods: We conducted a real-world crossover study with repeated measures of 30 healthy adults. Participants completed four 2-h exposure scenarios that included either rest or intermittent exercise in high- and low-traffic environments. Measures of respiratory function were collected at three time points. Pre-exposure to TRAP was ascertained from land-use-modeled address-attributed values. Mixed-effects models were used to estimate the impact of TRAP and PA on respiratory measures as well as potential effect modifications. Results: We found that PA was associated with a statistically significant increases of FEV1 (48.5 mL, p = 0.02), FEV1/FVC (0.64%, p = 0.005) and FEF25–75% (97.8 mL, p = 0.02). An increase in exposure to one unit (1 μg/m3) of PMcoarse was associated with a decrease in FEV1 (− 1.31 mL, p = 0.02) and FVC (− 1.71 mL, p = 0.01), respectively. On the other hand, for an otherwise equivalent exposure an increase of PA by one unit (1%Heart rate max) was found to reduce the immediate negative effects of particulate matter (PM) upon PEF (PM2.5, 0.02 L/min, p = 0.047; PM10, 0.02 L/min p = 0.02; PMcoarse, 0.03 L/min, p = 0.02) and the several hours delayed negative effects of PM upon FVC (PMcoarse, 0.11 mL, p = 0.02). The negative impact of exposure to TRAP constituents on FEV1/FVC and PEF was attenuated in those participants with higher TRAP pre-exposure levels. Conclusions: Our results suggest that associations between various pollutant exposures and respiratory measures are modified by the level of PA during exposure and TRAP pre-exposure of participants.
Keywords
traffic-related air pollution, physical activity, particulate matter, short term, crossover study, inhalation exposure
Date
2016
Type
Journal article
Journal
Environment International
Book
Volume
97
Issue
Page Range
45-55
Article Number
ACU Department
Mary MacKillop Institute for Health Research
Faculty of Health Sciences
Faculty of Health Sciences
Collections
Relation URI
Source URL
Event URL
Open Access Status
License
File Access
Controlled